التفاصيل البيبلوغرافية
| العنوان: |
A Comparison of the Process of Remodeling of Hydroxyapatite/Poly-D/L-Lactide and Beta-Tricalcium Phosphate in a Loading Site. |
| المؤلفون: |
Akagi, Hiroyuki1 hiroyuki-akagi@hotmail.co.jp, Ochi, Hiroki2 hiroki.vet101@gmail.com, Soeta, Satoshi3 s-soeta@nvlu.ac.jp, Kanno, Nobuo1 n.kanno7@gmail.com, Yoshihara, Megumi4 m-yoshihara@takiron.co.jp, Okazaki, Kenshi4 ken-oka@takiron.co.jp, Yogo, Takuya1 yogo3@nvlu.ac.jp, Harada, Yasuji1 harada@nvlu.ac.jp, Amasaki, Hajime3 hamasaki@nvlu.ac.jp, Hara, Yasushi1 hara@nvlu.ac.jp |
| المصدر: |
BioMed Research International. 10/4/2015, Vol. 2015, p1-14. 14p. |
| مصطلحات موضوعية: |
*HYDROXYAPATITE, *POLYLACTIC acid, *CALCIUM phosphate, *TISSUE scaffolds, *HISTOLOGY, *IMMUNOHISTOCHEMISTRY, *VON Willebrand factor, *CATHEPSINS |
| مستخلص: |
Currently, the most commonly used bioresorbable scaffold is made of beta-tricalcium phosphate (β-TCP); it is hoped that scaffolds made of a mixture of hydroxyapatite (HA) and poly-D/L-lactide (PDLLA) will be able to act as novel bioresorbable scaffolds. The aim of this study was to evaluate the utility of a HA/PDLLA scaffold compared to β-TCP, at a loading site. Dogs underwent surgery to replace a section of tibial bone with a bioresorbable scaffold. After the follow-up period, the scaffold was subjected to histological analysis. The HA/PDLLA scaffold showed similar bone formation and superior cell and tissue infiltration compared to the β-TCP scaffold, as seen after Villanueva Goldner staining. Moreover, silver staining and immunohistochemistry for Von Willebrand factor and cathepsin K demonstrated better cell infiltration in the HA/PDLLA scaffold. The fibrous tissue and cells that had infiltrated into the HA/PDLLA scaffold tested positive for collagen type I and RUNX2, respectively, indicating that the tissue and cells that had infiltrated into the HA/PDLLA scaffold had the potential to differentiate into bone. The HA/PDLLA scaffold is therefore likely to find clinical application as a new bioresorbable scaffold. [ABSTRACT FROM AUTHOR] |
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