Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma
| العنوان: | Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma |
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| المؤلفون: | Abraham S. Kanate, Mehdi Hamadani, Mohamed A. Kharfan-Dabaja |
| المصدر: | Bone Marrow Research, Vol 2012 (2012) Bone Marrow Research |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Pathology, Allogeneic transplantation, Hematopoietic cell, business.industry, lcsh:RC633-647.5, Immunology, Follicular lymphoma, Cell Biology, Hematology, Disease, Review Article, lcsh:Diseases of the blood and blood-forming organs, Follicular non-Hodgkin lymphoma, medicine.disease, Lymphoma, Transplantation, surgical procedures, operative, Chemoimmunotherapy, Internal medicine, hemic and lymphatic diseases, medicine, business |
| الوصف: | Commonly designated as an indolent non-Hodgkin lymphoma, follicular lymphoma (FL) presents with striking pathobiological and clinical heterogeneity. Initial management strategies for FL have evolved to involve combination chemoimmunotherapy and/or radio-immunoconjugates. Unfortunately even with the best available nontransplant treatment, which nowadays results in higher frequency of response, FL remains incurable. Although considered a feasible therapeutic option, the use of hematopoietic cell transplantation (HCT) remains controversial. The appropriate timing, graft source, and intensity of HCT conditioning regimens in FL are often matters of debate. Herein we review the available published data pertaining to the use of autologous or allogeneic HCT in patients with FL across different stages of the disease, discuss major recent advances in the field, and highlight avenues for future research. The current literature does not support a role of HCT for FL in first remission, but in the relapsed setting autologous HCT remains appropriate for patients with early chemosensitive relapses, while allogeneic transplantation remains the sole curative modality for this disease, in relatively younger patients without significant comorbidities. |
| اللغة: | English |
| تدمد: | 2090-3006 2090-2999 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7279ef0b3eeef2d0055c2569cc3077e1Test https://doaj.org/article/eee7e9bce0c6422d9d76486f1245da43Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7279ef0b3eeef2d0055c2569cc3077e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20903006 20902999 |
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