Effect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes
| العنوان: | Effect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes |
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| المؤلفون: | Krisztina Nagy, Attila Gergely Végh, Gábor Rákhely, Zoltán Bálint, Zsolt Szegletes, György Váró, Ádám Kerényi |
| المصدر: | Journal of Biomedicine and Biotechnology, Vol 2011 (2011) Journal of Biomedicine and Biotechnology |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Halobacterium salinarum, Article Subject, 1,2-Dipalmitoylphosphatidylcholine, Health, Toxicology and Mutagenesis, lcsh:Biotechnology, Lipid Bilayers, lcsh:Medicine, Peptide, Biology, Microscopy, Atomic Force, chemistry.chemical_compound, Anti-Infective Agents, Purple Membrane, Amide, lcsh:TP248.13-248.65, Genetics, Lipid bilayer, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, lcsh:R, Tryptophan, Biological membrane, General Medicine, biology.organism_classification, Membrane, chemistry, Biochemistry, Biophysics, Indolicidin, Molecular Medicine, Antimicrobial Cationic Peptides, Research Article, Biotechnology |
| الوصف: | Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues. Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet. We report here anin situatomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC) and on purple membrane ofHalobacterium salinarum. Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane. Purple membrane was much more resistant against indolicidin, probably due to its high protein content. Indolicidin preferred the border of membrane disks, where the lipids are more accessible. These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1110-7251 1110-7243 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd3bca30214181d6a20d2536aa7d3d6Test https://doaj.org/article/bd457a3025114904a2e7d141d35aec7cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3cd3bca30214181d6a20d2536aa7d3d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11107251 11107243 |
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