Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation
| العنوان: | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
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| المؤلفون: | Xiong Chen, Yiyi Jin, Weiwei Zhu, Weixin Li, Xiaodong Bao, Suqing Zheng, Li Li, Xin Ju, Zhongxiang Xiao, Guang Liang, Jianchang Qian, Xuemei Chen, Wencan Wu |
| المصدر: | Mediators of Inflammation Mediators of Inflammation, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Article Subject, medicine.medical_treatment, Acute Lung Injury, Immunology, Active Transport, Cell Nucleus, Anti-Inflammatory Agents, Enzyme-Linked Immunosorbent Assay, Inflammation, Pharmacology, Lung injury, Real-Time Polymerase Chain Reaction, Pathogenesis, Mice, 03 medical and health sciences, chemistry.chemical_compound, Adjuvants, Immunologic, Coumarins, In vivo, lcsh:Pathology, medicine, Animals, Mice, Inbred ICR, Tumor Necrosis Factor-alpha, business.industry, Septic shock, Macrophages, NF-kappa B, Acute kidney injury, NF-κB, Lung Injury, Cell Biology, respiratory system, medicine.disease, respiratory tract diseases, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, chemistry, medicine.symptom, business, Bronchoalveolar Lavage Fluid, lcsh:RB1-214, Research Article |
| الوصف: | Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury. |
| وصف الملف: | text/xhtml |
| تدمد: | 1466-1861 0962-9351 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18609208695810177fdf207ace586796Test https://doi.org/10.1155/2018/4934592Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....18609208695810177fdf207ace586796 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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