Cabergoline reverses cortical hyperexcitability in patients with restless legs syndrome
| العنوان: | Cabergoline reverses cortical hyperexcitability in patients with restless legs syndrome |
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| المؤلفون: | Piergiorgio Lochner, Arianna Bratti, Roland Marth, Harald Ausserer, Raffaele Nardone, Markus Covi, Frediano Tezzon |
| المصدر: | Acta Neurologica Scandinavica. 114:244-249 |
| بيانات النشر: | Hindawi Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, Agonist, medicine.medical_specialty, Cabergoline, medicine.drug_class, Dopamine, medicine.medical_treatment, Neural Conduction, Pyramidal Tracts, Synaptic Transmission, Dopamine agonist, Membrane Potentials, Restless Legs Syndrome, Internal medicine, mental disorders, Reaction Time, medicine, Humans, Restless legs syndrome, Ergolines, Aged, Neurons, Brain Diseases, business.industry, Dopaminergic, Motor Cortex, Neural Inhibition, General Medicine, Middle Aged, medicine.disease, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Treatment Outcome, Endocrinology, medicine.anatomical_structure, Neurology, Dopamine Agonists, Female, Silent period, Neurology (clinical), business, Motor cortex, medicine.drug |
| الوصف: | Objective – To reverse the profile of abnormal intracortical excitability in patients with restless legs syndrome (RLS) by administering the dopaminergic agonist cabergoline. Methods – The effects of this drug on motor cortex excitability were examined with a range of transcranial magnetic stimulation (TMS) protocols before and after administration of cabergoline over a period of 4 weeks in 14 patients with RLS and in 15 healthy volunteers. Measures of cortical excitability included central motor conduction time; resting and active motor threshold to TMS; duration of the cortical silent period; short latency intracortical inhibition (SICI) and intracortical facilitation using a paired-pulse TMS technique. Results – Short latency intracortical inhibition was significantly reduced in RLS patients compared with the controls and this abnormal profile was reversed by treatment with cabergoline; the other TMS parameters did not differ significantly from the controls and remained unaffected after treatment with cabergoline. Cabergoline had no effect on cortical excitability of the normal subjects. Conclusions – As dopaminergic drugs are known to increase SICI, our findings suggest that RLS may be caused by a central nervous system dopaminergic dysfunction. This study demonstrates that the cortical hyperexcitability of RLS is reversed by cabergoline, and provides physiological evidence that this dopamine agonist may be a potentially efficacious option for the treatment of RLS. |
| تدمد: | 1600-0404 0001-6314 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40f1eab145071b9b2b4fe76afa9ca27Test https://doi.org/10.1111/j.1600-0404.2006.00669.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d40f1eab145071b9b2b4fe76afa9ca27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000404 00016314 |
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