Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis
| العنوان: | Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis |
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| المؤلفون: | Lishi Li, Sanbao Chai, Yuan Zhang, Linong Ji, Kai Yu, Shanshan Wu, Siyan Zhan, Zhirong Yang, Feng Sun |
| المصدر: | Journal of Diabetes Research, Vol 2015 (2015) Journal of Diabetes Research |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Review Article, Cochrane Library, Pharmacology, Placebo, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Drug Administration Schedule, Glucagon-Like Peptide-1 Receptor, law.invention, Endocrinology, Randomized controlled trial, law, Weight loss, Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, Weight Loss, medicine, Receptors, Glucagon, Humans, Hypoglycemic Agents, Insulin, Obesity, Randomized Controlled Trials as Topic, lcsh:RC648-665, Liraglutide, business.industry, Venoms, Overweight, medicine.disease, Diabetes Mellitus, Type 2, Exenatide, medicine.symptom, business, Peptides, medicine.drug |
| الوصف: | To evaluate the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on weight reduction in patients with Type 2 diabetes mellitus (Type 2 DM), a network meta-analysis was conducted. MEDLINE, EMBASE, Cochrane Library, and ClinicalTrials.gov were searched from 1950 to October 2013. Randomized controlled trials (RCTs) involving GLP-1 RAs were included if they provided information on body weight. A total of 51 RCTs were included and 17521 participants were enrolled. The mean duration of 51 RCTs was 31 weeks. Exenatide 10 μg twice daily (EX10BID) reduced weight compared with exenatide 5 μg twice daily (EX5BID), liraglutide 0.6 mg once daily (LIR0.6QD), liraglutide—1.2 mg once daily (LIR1.2QD), and placebo treatment, with mean differences of −1.07 kg (95% CI: −2.41, −0.02), −2.38 kg (95% CI: −3.71, −1.06), −1.62 kg (95% CI: −2.79, −0.43), and −1.92 kg (95% CI: −2.61, −1.24), respectively. Reductions of weight treated with liraglutide—1.8 mg once daily (LIR1.8QD) reach statistical significance (−1.43 kg (95% CI: −2.73, −0.15)) versus LIR1.2QD and (−0.98 kg (95% CI: −1.94, −0.02)) versus placebo. Network meta-analysis found that EX10BID, LIR1.8QD, and EX2QW obtained a higher proportion of patients with weight loss than other traditional hypoglycemic agents. Our results suggest GLP-1 RAs are promising candidates for weight control in comparison with traditional hypoglycemic drugs, and EX10BID, LIR1.8QD, and EX2QW rank the top three drugs. |
| اللغة: | English |
| تدمد: | 2314-6753 2314-6745 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7e4bf1df897769a55bbffc77afec4eTest https://doaj.org/article/a12ef9637bb6484c9b1e9c7ee9cfc5b3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a7e4bf1df897769a55bbffc77afec4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146753 23146745 |
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