Sphingosine 1-Phosphate Distribution in Human Plasma: Associations with Lipid Profiles
| العنوان: | Sphingosine 1-Phosphate Distribution in Human Plasma: Associations with Lipid Profiles |
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| المؤلفون: | Samar M. Hammad, Andrea J. Semler, Mohammed M. Al Gadban, Richard L. Klein |
| المصدر: | Journal of Lipids, Vol 2012 (2012) Journal of Lipids |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Very low-density lipoprotein, Ceramide, medicine.medical_specialty, Article Subject, 030204 cardiovascular system & hematology, Biochemistry, lcsh:Physiology, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, lcsh:QD415-436, Sphingosine-1-phosphate, 030304 developmental biology, 0303 health sciences, Sphingosine, lcsh:QP1-981, organic chemicals, Sphingolipid, Blood proteins, Endocrinology, chemistry, Immunology, lipids (amino acids, peptides, and proteins), Sphingomyelin, Research Article, Lipoprotein |
| الوصف: | The physiological significance of sphingosine 1-phosphate (S1P) transport in blood has been debated. We have recently reported a comprehensive sphingolipid profile in human plasma and lipoprotein particles (VLDL, LDL, and HDL) using HPLC-MS/MS (Hammad et al., 2010). We now determined the relative concentrations of sphingolipids including S1P in the plasma subfraction containing lipoproteins compared to those in the remaining plasma proteins. Sphingomyelin and ceramide were predominantly recovered in the lipoprotein-containing fraction. Total plasma S1P concentration was positively correlated with S1P concentration in the protein-containing fraction, but not with S1P concentration in the lipoprotein-containing fraction. The percentage of S1P transported in plasma lipoproteins was positively correlated with HDL cholesterol (HDL-C) concentration; however, S1P transport in lipoproteins was not limited by the concentration of HDL-C in the individual subject. Thus, different plasma pools of S1P may have different contributions to S1P signaling in health and disease. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2090-3049 2090-3030 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3cc8f46c7d28ec88a5e960ebdb25e5Test https://doaj.org/article/92efd456ddf04fb5a2882d6e3f4a92b4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0a3cc8f46c7d28ec88a5e960ebdb25e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20903049 20903030 |
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