Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer
| العنوان: | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
|---|---|
| المؤلفون: | Nikos F. Vlahos, Athanasia Pavlidou |
| المصدر: | The Scientific World Journal The Scientific World Journal, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Proto-Oncogene Proteins c-akt, Drug Evaluation, Preclinical, lcsh:Medicine, Antineoplastic Agents, Review Article, Biology, lcsh:Technology, General Biochemistry, Genetics and Molecular Biology, Phosphatidylinositol 3-Kinases, medicine, Animals, Humans, Genetic Predisposition to Disease, Molecular Targeted Therapy, lcsh:Science, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, General Environmental Science, Clinical Trials as Topic, lcsh:T, TOR Serine-Threonine Kinases, Endometrial cancer, lcsh:R, Cancer, General Medicine, medicine.disease, Discovery and development of mTOR inhibitors, Endometrial Neoplasms, Drug Resistance, Neoplasm, Immunology, Cancer research, lcsh:Q, Female, Signal transduction, Signal Transduction |
| الوصف: | It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers. Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer. This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented. |
| تدمد: | 1537-744X 2356-6140 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb264241a30b3a83090a2a77bf24f2bTest https://doi.org/10.1155/2014/709736Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ecb264241a30b3a83090a2a77bf24f2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1537744X 23566140 |
|---|