The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes
| العنوان: | The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
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| المؤلفون: | Mats Bojestig, Hans J. Arnqvist, Johnny Ludvigsson, Bengt E. Karlberg, Fredrik H. Nystrom |
| المصدر: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 1 (2000) Europe PubMed Central |
| بيانات النشر: | Hindawi Limited, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, Medicine (General), medicine.medical_specialty, 030204 cardiovascular system & hematology, Plasma renin activity, Renin-Angiotensin System, 03 medical and health sciences, chemistry.chemical_compound, R5-920, 0302 clinical medicine, Endocrinology, Atrial natriuretic peptide, Internal medicine, Diabetes mellitus, Renin, Renin–angiotensin system, Internal Medicine, Albuminuria, Humans, Medicine, Aldosterone, Glycated Hemoglobin, Type 1 diabetes, business.industry, Angiotensin II, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Female, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Poor glycaemic control and high blood pressure are two important risk factors for the development of retinopathy and nephropathy in Type 1 diabetes. The renin-angiotensin-aldosterone system (RAAS) may be involved in this process, since treatment with angiotensin-converting enzyme (ACE) inhibitors postpones the development of these complications. We investigated whether plasma renin activity (PRA), plasma angiotensin II (Ang II) and atrial natriuretic peptide (ANP) differed in Type 1 diabetic patients compared with healthy controls. We recruited 80 patients with Type 1 diabetes of more than 10 years' duration and 75 age-matched controls. We found that PRA and Ang II concentrations were significantly lower in patients than in the controls. The levels of ANP, on the other hand, were higher in patients than in controls. PRA correlated negatively to the mean value of HbA1c during the previous five years. PRA and Ang II were significantly lower in patients with mean HbA1c >8.4% compared with those with mean HbA1c |
| تدمد: | 1752-8976 1470-3203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd242f1a3480f30d5cf9cdc2a1d527bTest https://doi.org/10.3317/jraas.2000.065Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7bd242f1a3480f30d5cf9cdc2a1d527b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17528976 14703203 |
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