دورية أكاديمية
Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises
| العنوان: | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
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| المؤلفون: | Guillaume Pierre Charles George, Federica Pisaneschi, Quang-Dé Nguyen, Eric Ofori Aboagye |
| المصدر: | Molecular Imaging, Vol 14 (2015) |
| بيانات النشر: | Hindawi - SAGE Publishing |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Medical technology, R855-855.5 |
| الوصف: | Molecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4), a chemokine receptor that has been associated with tumor metastasis, has become an area of intensive research. This review article focuses on positron emission tomography (PET) and aims to provide useful and critical insights into the application of PET to characterize CXCR4 expression, including the chemical, radiosynthetic, and biological requirements for PET radiotracers. This discussion is informed by a summary of the different approaches taken so far and a comparison of their clinical translation. Finally, our expert opinions as to potential future advances in the field are expressed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1536-0121 |
| العلاقة: | https://doi.org/10.2310/7290.2014.00041Test; https://doaj.org/toc/1536-0121Test; https://doaj.org/article/d4075b4979d449bb8ab1152070228406Test |
| DOI: | 10.2310/7290.2014.00041 |
| الإتاحة: | https://doi.org/10.2310/7290.2014.00041Test https://doaj.org/article/d4075b4979d449bb8ab1152070228406Test |
| رقم الانضمام: | edsbas.CC1DD8E1 |
| قاعدة البيانات: | BASE |
| تدمد: | 15360121 |
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| DOI: | 10.2310/7290.2014.00041 |