Neutrophil to Lymphocyte Ratio as a Predictor of Poor Prognosis in Metastatic Pancreatic Cancer Patients Treated with Nab-Paclitaxel plus Gemcitabine: A Propensity Score Analysis
| العنوان: | Neutrophil to Lymphocyte Ratio as a Predictor of Poor Prognosis in Metastatic Pancreatic Cancer Patients Treated with Nab-Paclitaxel plus Gemcitabine: A Propensity Score Analysis |
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| المؤلفون: | Luca Pompella, Teresa Troiani, F. De Vita, A. Diana, Francesco Iovino, Angelica Petrillo, B. Savastano, Jole Ventriglia, E. Martinelli, Giuseppe Tirino, F. Morgillo, Maria Maddalena Laterza, M. Huerta Alvaro, Andrés Cervantes, Michele Orditura, Valentina Gambardella, Fortunato Ciardiello |
| المساهمون: | Ventriglia, J, Petrillo, A, Huerta Alváro, M, Laterza, M M, Savastano, B, Gambardella, V, Tirino, G, Pompella, L, Diana, A, Iovino, F, Troiani, T, Martinelli, E, Morgillo, F, Orditura, M, Cervantes, A, Ciardiello, F, De Vita, F |
| المصدر: | Gastroenterology Research and Practice r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname Gastroenterology Research and Practice, Vol 2018 (2018) |
| بيانات النشر: | Hindawi, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Article Subject, medicine.medical_treatment, Gastroenterology, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Pancreatic cancer, medicine, Neutrophil to lymphocyte ratio, lcsh:RC799-869, Chemotherapy, Hepatology, Proportional hazards model, business.industry, medicine.disease, Primary tumor, Gemcitabine, 030104 developmental biology, 030220 oncology & carcinogenesis, Propensity score matching, lcsh:Diseases of the digestive system. Gastroenterology, business, medicine.drug, Research Article |
| الوصف: | Background. High neutrophil to lymphocyte ratio (NLR) has shown to be a predictor of poor outcomes in various malignancies, including pancreatic cancer. Methods. We assessed 70 consecutive pts with histologically confirmed mPC who received chemotherapy with nab-paclitaxel/gemcitabine at two different European oncologic centers between January 2012 and November 2015. Variables assessed for prognostic correlations included age ≥ 66, sex, Karnofsky PS score, primary tumor site, baseline CA19.9 level ≥ 59xULN, 12-week decrease of the CA19.9 level ≥ 50% from baseline, basal bilirubin level, baseline NLR, biliary stent implantation, and liver metastasis. Survival analyses were generated according to the Kaplan-Meier method. Univariate and multivariate analyses were performed by a Cox proportional hazard model. Results. According to NLR values, the patients were divided into two groups: high and low. Low group patients showed a better median PFS (7 months versus 5 months) and median OS (13 months versus 7 months) in respect to high group patients. At multivariate analysis, Karnofsky PS Conclusions. Baseline NLR is an independent predictor of survival of patients with mPC receiving palliative chemotherapy and could be useful to develop a simple clinical score to identify a subgroup of patients with a low chance to benefit from chemotherapy. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1687-630X 1687-6121 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc8fb52612c2e6b3f7866629d24e847Test http://europepmc.org/articles/PMC6015665Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9dc8fb52612c2e6b3f7866629d24e847 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1687630X 16876121 |
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