Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in ob/ob Mice
| العنوان: | Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in ob/ob Mice |
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| المؤلفون: | Koffi, Camille, Soleti, Raffaella, Nitiema, Mathieu, Mallegol, Patricia, Hilairet, Gregory, Chaigneau, Julien, Boursier, Jerome, Kamagate, Mamadou, Le Lay, Soazig, Die-Kakou, Henri Maxime, Andriantsitohaina, Ramaroson |
| المساهمون: | Department of Pharmacology [Abidjan, Côte d’Ivoire] (UFR-SMA), University of Felix Houphouët Boigny [Abidjan, Ivory Coast], Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Laboratory of Clinical Pharmacology [Bouaké, Côte d’Ivoire], University of Alassane Ouattara [Bouaké, Côte d’Ivoire], SOLETI, Raffaella, Université Félix Houphouët-Boigny (UFHB) |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Hindawi, 2019, 2019, pp.6560498. ⟨10.1155/2019/6560498⟩ Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity, 2019, 2019, pp.6560498. ⟨10.1155/2019/6560498⟩ |
| بيانات النشر: | Hindawi, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Ethanol, [SDV.BA] Life Sciences [q-bio]/Animal biology, Article Subject, Plant Extracts, lcsh:Cytology, [SDV]Life Sciences [q-bio], [SDV.BA]Life Sciences [q-bio]/Animal biology, Cassia, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Plant Leaves, [SDV] Life Sciences [q-bio], [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Mice, Diabetes Mellitus, Type 2, Animals, Female, Insulin Resistance, lcsh:QH573-671, Research Article |
| الوصف: | International audience; Despite long traditional utilization and some reports on the antihyperglycemic and antihyperlipidemic action of Cassia siamea, the mechanisms involved have not been investigated yet. Thus, the objective of the present study was to investigate whether and how oral administration of the ethanolic extract of Cassia siamea Lam leaves (LECS) improves glucose and insulin homoeostasis, liver damage, and endothelial dysfunction in an experimental model of type 2 diabetes, the leptin-deficient ob/ob mice. Oxidative stress and protein expression of insulin-dependent and insulin -independent signaling pathways were studied. Obese ( ob/ob) vs. control (ob/+) mice were treated daily with intragastric administration of either vehicle or LECS (200 mg/kg, per day) for 4 weeks. Fasting blood glucose, body weight, food intake, glucose and insulin tolerance, oxidative stress, and liver damage as well as vascular complications with respect to endothelial dysfunction were examined. Administration of LECS in obese mice significantly reduced blood glucose and insulin levels, improved glucose tolerance and insulin sensitivity, and restored the increase of circulating AST and ALT without modification of body weight and food intake. These effects were associated with increased activity of both insulin and AMPK pathways in the liver and skeletal muscles. Of particular interest, administration of LECS in obese mice completely prevented the endothelial dysfunction resulting from an increased NO· and decreased reactive oxygen species (ROS) production in the aorta. Altogether, oral administration of LECS remarkably attenuates features of type 2 diabetes on glucose, hepatic inflammation, insulin resistance, endothelial function, and vascular oxidative stress, being as most of these effects are related to insulin-dependent and insulin-independent mechanisms. Therefore, this study points for the therapeutic potential of Cassia siamea in correcting both metabolic and vascular alterations linked to type 2 diabetes. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0900 1942-0994 |
| DOI: | 10.1155/2019/6560498 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8aa43d58daf9e1026a8ae2a50c39564bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....8aa43d58daf9e1026a8ae2a50c39564b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420900 19420994 |
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| DOI: | 10.1155/2019/6560498 |