Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse
| العنوان: | Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse |
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| المؤلفون: | Remo Sanges, Gabriella De Vita, Antonio Nardone, Swaraj Basu, Luigi Di Guida, Miriane de Oliveira, Nicole Lewin, Mario De Felice, Barbara D'Andrea, Elena Amendola, Sara Carmela Credendino |
| المساهمون: | Università degli Studi di Napoli Federico II, Universidade de São Paulo (USP), University of Gothenburg, Stazione Zoologica Anton Dohrn, Credendino, SARA CARMELA, Lewin, Nicole, DE OLIVEIRA, Miriane, Basu, Swaraj, D'Andrea, Barbara, Amendola, Elena, DI GUIDA, Luigi, Nardone, Antonio, Sanges, Remo, De Felice, Mario, De Vita, Gabriella |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP INTERNATIONAL JOURNAL OF GENOMICS 2017 (2017). doi:10.1155/2017/9769171 info:cnr-pdr/source/autori:Credendino S.C.; Lewin N.; De Oliveira M.; Basu S.; D'Andrea B.; Amendola E.; Di Guida L.; Nardone A.; Sanges R.; De Felice M.; De Vita G./titolo:Tissue-and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse/doi:10.1155%2F2017%2F9769171/rivista:INTERNATIONAL JOURNAL OF GENOMICS/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:2017 International Journal of Genomics, Vol 2017 (2017) International Journal of Genomics |
| بيانات النشر: | Hindawi, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Gene isoform, lcsh:QH426-470, Article Subject, Cell, Pharmaceutical Science, Context (language use), In situ hybridization, Biology, Biochemistry, 03 medical and health sciences, Genetic, Settore BIO/13 - Biologia Applicata, Genetics, medicine, Molecular Biology, Gene, Thyroid, Long non-coding RNA, Cell biology, lcsh:Genetics, 030104 developmental biology, medicine.anatomical_structure, RNA splicing, Cell Type, Long Noncoding, RNA, Klhl14-AS, Mouse, Research Article |
| الوصف: | Made available in DSpace on 2022-04-29T08:45:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 European Commission lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-AS in a panel of adult mouse tissues, showing that it is expressed in the thyroid, lung, kidney, testis, ovary, brain, and spleen, although at different levels. In situ hybridization analysis reveals that, in the context of each organ, Klhl14-AS shows a cell type-specific expression. Interestingly, databases report a similar expression profile for human Klhl14-AS. Our observations suggest that this lncRNA could play cell type-specific roles in several organs and pave the way for functional characterization of this gene in appropriate biological contexts. Dipartimento di Medicina Molecolare e Biotecnologie Mediche Università degli Studi di Napoli Federico II, Via S. Pansini 5 Department of Internal Medicine Botucatu School of Medicine University of São Paulo State Department of Medical Biochemistry and Cell Biology Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Dipartimento di Sanità Pubblica Università degli Studi di Napoli Federico II, Via S. Pansini 5 Biology and Evolution of Marine Organisms Stazione Zoologica Anton Dohrn, Villa Comunale 1 European Commission: RNA-REGULOMICS 318981 |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-436X |
| DOI: | 10.1155/2017/9769171 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8036f647947534dcc75b380f3b044debTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8036f647947534dcc75b380f3b044deb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2314436X |
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| DOI: | 10.1155/2017/9769171 |