دورية أكاديمية
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
| العنوان: | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis |
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| المؤلفون: | Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Proia, Richard L., von Bruehl, Marie-Luise, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, Billich, Andreas, Sixt, Michael, von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen, Tirniceriu, Anca, Gaertner, Florian, von Baumgarten, Louisa, Faessler, Reinhard |
| بيانات النشر: | Highwire Press |
| سنة النشر: | 2012 |
| المجموعة: | The Novartis Repository (Novartis, Switzerland) |
| الوصف: | Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the lipid mediator sphingosine 1-phosphate (S1P) serves as critical directional cue guiding the elongation of megakaryocytic proplatelet extensions from the interstitium into BM sinusoids and triggering the subsequent shedding of proplatelets into the blood. Correspondingly, mice lacking the S1P receptor S1pr1 develop severe thrombocytopenia due to both formation of aberrant extravascular proplatelets and defective intravascular proplatelet shedding. By contrast, activation of S1pr1 signaling leads to the prompt release of new platelets into the circulating blood. Taken together, our findings uncover a novel function of the S1P/S1pr1 axis as master regulator of efficient thrombopoiesis and might raise new therapeutic options for patients with thrombocytopenia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Proia, Richard L., von Bruehl, Marie-Luise, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, Billich, Andreas, Sixt, Michael, von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen, Tirniceriu, Anca, Gaertner, Florian, von Baumgarten, Louisa and Faessler, Reinhard (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209 (12). pp. 2165-2181. ISSN 0022-1007; PMID: 23148237; doi:10.1084/jem.20121090 |
| DOI: | 10.1084/jem.20121090 |
| الإتاحة: | https://doi.org/10.1084/jem.20121090Test https://oak.novartis.com/2282Test/ |
| رقم الانضمام: | edsbas.2D569CEE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20121090 |
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