دورية أكاديمية
Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes on
| العنوان: | Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes on |
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| المؤلفون: | Seban, Romain-David, Richard, Capucine, Nascimento-Leite, Camila, Ghidaglia, Jerome, Provost, Claire, Gonin, Julie, Tourneau, Christophe Le, Romano, Emanuela, Deleval, Nicolas, Champion, Laurence |
| المصدر: | J Nucl Med ; ISSN:1535-5667 ; Volume:63 ; Issue:8 |
| بيانات النشر: | HighWire |
| سنة النشر: | 2022 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | 18F-FDG PET/CT, COVID-19 vaccination, absolute lymphocyte count, hypermetabolic lymph nodes, immune response |
| الوصف: | We aimed to predict the presence of vaccine-induced hypermetabolic lymph nodes (v-HLNs) on 18F-FDG PET/CT after coronavirus disease 2019 (COVID-19) vaccination and determine their association with lymphocyte counts. Methods: In this retrospective single-center study, we included consecutive patients who underwent 18F-FDG PET/CT imaging after messenger RNA- or viral vector-based COVID-19 vaccination between early March and late April 2021. Demographics, clinical parameters, and absolute lymphocyte count (ALC) were collected, and their association with the presence of v-HLNs in the draining territory was studied by logistic regression. Results: In total, 260 patients were eligible, including 209 (80%) women and 145 (56%) with breast cancer. The median age was 50 y (range, 23-96 y). The messenger RNA vaccine had been given to 233 (90%). Ninety (35%) patients had v-HLNs, with a median SUVmax of 3.7 (range, 2.0-26.3), and 74 (44%) displayed lymphopenia, with a median ALC of 1.4 × 109/L (range, 0.3-18.3 × 109/L). An age of no more than 50 y (odds ratio [OR], 2.2; 95% CI, 1.0-4.5), the absence of lymphopenia (OR, 2.2; 95% CI, 1.1-4.3), and less than a 30-d interval from the last vaccine injection to the 18F-FDG PET/CT (OR, 2.6; 95% CI, 1.3-5.6) were independent factors for v-HLNs on multivariate analysis. In breast cancer patients, the absence of lymphopenia was the only independent factor significantly associated with v-HLNs (OR, 2.9; 95% CI, 1.2-7.4). Conclusion: Patients with a normal ALC after COVID-19 vaccination were more likely to have v-HLNs on 18F-FDG PET/CT, both of which might be associated with a stronger immune response to vaccination. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.2967/jnumed.121.263082Test; https://pubmed.ncbi.nlm.nih.gov/34857663Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364344Test/ |
| DOI: | 10.2967/jnumed.121.263082 |
| الإتاحة: | https://doi.org/10.2967/jnumed.121.263082Test https://pubmed.ncbi.nlm.nih.gov/34857663Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364344Test/ |
| حقوق: | © 2022 by the Society of Nuclear Medicine and Molecular Imaging. |
| رقم الانضمام: | edsbas.496BF1DE |
| قاعدة البيانات: | BASE |
| DOI: | 10.2967/jnumed.121.263082 |
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