دورية أكاديمية
Solitary Fibrous Tumour of the Genitourinary Tract: A Clinicopathological Study of 11 Cases and Their Association with the NAB2-STAT6 Fusion Gene
| العنوان: | Solitary Fibrous Tumour of the Genitourinary Tract: A Clinicopathological Study of 11 Cases and Their Association with the NAB2-STAT6 Fusion Gene |
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| المؤلفون: | Kouba, Erik, Simper, Novae B, Chen, Shaoxiong, Williamson, Sean R, Grignon, David J, Eble, John N, MacLennan, Gregory T, Montironi, Rodolfo, Lopez-Beltran, Antonio, Osunkoya, Adeboye O, Zhang, Shaobo, Wang, Mingsheng, Wang, Lisha, Tran, Thu, Emerson, Robert E, Baldrige, Lee A, Monn, M Francesca, Linos, Konstantinos, Cheng, Liang |
| المصدر: | Pathology and Laboratory Medicine Articles |
| بيانات النشر: | Henry Ford Health Scholarly Commons |
| سنة النشر: | 2017 |
| المجموعة: | Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: | Adolescent, Adrenal Gland Neoplasms, Adult, Child, Disease Progression, Female, Gene Fusion, Humans, Male, Middle Aged, Repressor Proteins, STAT6 Transcription Factor, Solitary Fibrous Tumors, Urogenital Neoplasms, Young Adult |
| الوصف: | Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2. Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours. Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlycommons.henryford.com/pathology_articles/97Test; http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:27802414Test |
| الإتاحة: | https://scholarlycommons.henryford.com/pathology_articles/97Test http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:27802414Test |
| رقم الانضمام: | edsbas.45B334AE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |