دورية أكاديمية
TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract
| العنوان: | TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract |
|---|---|
| المؤلفون: | Wang, Xiaoyan, Lopez-Beltran, Antonio, Osunkoya, Adeboye O, Wang, Mingsheng, Zhang, Shaobo, Davidson, Darrell D, Emerson, Robert E, Williamson, Sean R, Tan, Puay-Hoon, Kaimakliotis, Hristos Z, Baldridge, Lee A, MacLennan, Gregory T, Montironi, Rodolfo, Cheng, Liang |
| المصدر: | Pathology and Laboratory Medicine Articles |
| بيانات النشر: | Henry Ford Health Scholarly Commons |
| سنة النشر: | 2017 |
| المجموعة: | Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: | Aged, 80 and over, Biomarkers, Carcinoma, Female, GATA3 Transcription Factor, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Neoplasm Staging, PAX8 Transcription Factor, Prognosis, Promoter Regions, Genetic, Telomerase, Tumor Suppressor Protein p53, Urethral Neoplasms, Urologic Neoplasms |
| الوصف: | AIM: To determine TERT promoter mutation status as well as the expression of PAX8, GATA3, p63, p40, p53 and uroplakin III in 17 patients with the upper urinary tract sarcomatoid urothelial carcinoma. METHODS & RESULTS: TERT C228T mutations were found in six of 17 cases (35%). p53 was expressed in 77% of these tumors. PAX8, GATA3, p40 and uroplakin III are less frequently expressed. Lymph node metastases were present in ten cases (59%). Eight patients (47%), including all three patients with TERT mutation, died of cancer within 2 years after surgery. CONCLUSION: Sarcomatoid carcinoma of the upper urinary tract is an aggressive tumor and the presence of TERT mutation may portend poor prognosis. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlycommons.henryford.com/pathology_articles/175Test; http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:28052688Test |
| الإتاحة: | https://scholarlycommons.henryford.com/pathology_articles/175Test http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:28052688Test |
| رقم الانضمام: | edsbas.CA5F0E7D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |