مورد إلكتروني
Effects of gamma-tocopherol supplementation on thrombotic risk factors
| العنوان: | Effects of gamma-tocopherol supplementation on thrombotic risk factors |
|---|---|
| بيانات النشر: | HEC Press 2007-09-01 |
| تفاصيل مُضافة: | Singh, Indu Turner, Alan Sinclair, Andrew Li, Duo Hawley, John |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gammatocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity. |
| مصطلحات الفهرس: | gamma tocopherol, platelets, lipids, CRP, thrombotic risk factors, Journal Article |
| URL: | issn: 0964-7058 issn: 1440-6047 Asia Pacific journal of clinical nutrition |
| الإتاحة: | Open access content. Open access content 2007, HEC Press |
| ملاحظة: | English |
| أرقام أخرى: | LD0 oai:dro.deakin.edu.au:DU:30007687 952400619 |
| المصدر المساهم: | DEAKIN UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn952400619 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |