دورية أكاديمية
An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma
| العنوان: | An international, multicenter, retrospective study on the positive impact of cutaneous involvement on the clinical outcome of adult T-cell leukemia/lymphoma |
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| المؤلفون: | Malpica, Luis, Castro, Denisse, Enriquez, Daniel J., Oviedo-Pecho, Roberto, Peña, Camila, Idrobo, Henry, Fiad, Lorena, Prates, Maria, Valcarcel, Bryan, Paredes, Antonio, Sánchez, Gadwyn, Moisés, Celia, Castillo, Jorge J., Villela, Luis, Ramos, Juan C., Biglione, Mirna, Beltran, Brady E. |
| المصدر: | GW Authored Works |
| بيانات النشر: | Health Sciences Research Commons |
| سنة النشر: | 2022 |
| المجموعة: | George Washington University: Health Sciences Research Commons (HSRC) |
| مصطلحات موضوعية: | Adult-T cell leukemia/lymphoma, ATLL, HTLV-1, interferon alpha, Latin America, skin lymphoma |
| الوصف: | Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral variant. Erythroderma (24%) and plaques (22%) were the most frequent skin lesions. The presence of cutaneous involvement was associated with better overall survival compared to non-cutaneous involvement (aHR 0.55 [95% CI: 0.37–0.82], p < 0.01; 1-year OS 53 vs. 27%, respectively, p = 0.012). Combination zidovudine and interferon-alpha (AZT-IFN) yielded high response rates (overall response, OR = 100%, n = 8; complete response 62.5%) compared to chemotherapy (OR = 33.3%, n = 12/36). In conclusion, cutaneous involvement was associated with better survival in Latin American patients with ATLL. AZT-IFN demonstrated encouraging responses in ATLL patients with cutaneous involvement. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://hsrc.himmelfarb.gwu.edu/gwhpubs/95Test; https://doi.org/10.1080/10428194.2021.1984455Test |
| DOI: | 10.1080/10428194.2021.1984455 |
| الإتاحة: | https://doi.org/10.1080/10428194.2021.1984455Test https://hsrc.himmelfarb.gwu.edu/gwhpubs/95Test |
| رقم الانضمام: | edsbas.5A22E9A2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10428194.2021.1984455 |
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