دورية أكاديمية
Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells
| العنوان: | Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells |
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| المؤلفون: | Troiani, T, Vecchione, Loredana, Martinelli, E, Capasso, A, Costantino, S, Ciuffreda, L P, Morgillo, F, Vitagliano, D, D'Aiuto, E, De Palma, R, Tejpar, Sabine, Van Cutsem, Eric, De Lorenzi, M, Caraglia, M, Berrino, L, Ciardiello, F |
| بيانات النشر: | Harcourt Publishers |
| سنة النشر: | 2012 |
| المجموعة: | KU Leuven: Lirias |
| مصطلحات موضوعية: | selumetinib, PKA, gene expression, gene mutations, cancer cell resistance, Apoptosis, Benzimidazoles, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Cyclic AMP-Dependent Protein Kinases, Drug Resistance, Neoplasm, Enzyme Activation, Gene Expression Profiling, Humans, Lung Neoplasms, Mitogen-Activated Protein Kinase Kinases, Mutation, Xenograft Model Antitumor Assays |
| الوصف: | MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. ; status: published |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0007-0920 1532-1827 |
| العلاقة: | British Journal of Cancer vol:106 issue:10 pages:1648-1659; https://lirias.kuleuven.be/handle/123456789/363100Test; http://dx.doi.org/10.1038/bjc.2012.129Test |
| DOI: | 10.1038/bjc.2012.129 |
| الإتاحة: | https://doi.org/10.1038/bjc.2012.129Test https://lirias.kuleuven.be/handle/123456789/363100Test |
| رقم الانضمام: | edsbas.D1CC87C1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00070920 15321827 |
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| DOI: | 10.1038/bjc.2012.129 |