Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium
| العنوان: | Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium |
|---|---|
| المؤلفون: | Weiva Sieh, Alice S. Whittemore, Satoyo Hosono, Francesmary Modugno, Ellen L. Goode, Joseph H. Rothstein, Elisa V. Bandera, Penelope M. Webb, Hoda Anton-Culver, Brooke L. Fridley, A. du Bois, Mary Anne Rossing, Ignace Vergote, Melissa C. Larson, Argyrios Ziogas, Sharon E. Johnatty, Sandrina Lambrechts, Jolanta Lissowska, Claus Høgdall, Jennifer A. Doherty, Keitaro Matsuo, Joellen M. Schildkraut, Allan Jensen, Anna H. Wu, Suzanne C. Dixon, N. Wentzensen, Roberta B. Ness, Rebecca Sutphen, M. W. Beckmann, Jillian Hung, Diether Lambrechts, Lorna Rodriguez-Rodriguez, Christina M. Nagle, Harvey A. Risch, Ira Schwaab, Daniel W. Cramer, Kathryn L. Terry, Robert A. Vierkant, Lisa E. Paddock, L A Brinton, K. Moysich, M. T. Goodman, Peter A. Fasching, E Van Nieuwenhuysen, Florian Heitz, Estrid Høgdall, Lene Lundvall, P. Harter, Celeste Leigh Pearce, Kristine G. Wicklund, Susanne K. Kjaer, Rachel Palmieri Weber, Hannah P. Yang, Sian Fereday, Jenny Chang-Claude, Valerie McGuire, Anna deFazio |
| المصدر: | Nagle, CM; Dixon, SC; Jensen, A; Kjaer, SK; Modugno, F; DeFazio, A; et al.(2015). Obesity and survival among women with ovarian cancer: Results from the Ovarian Cancer Association Consortium. British Journal of Cancer, 113(5), 817-826. doi: 10.1038/bjc.2015.245. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1kw0h9xzTest British Journal of Cancer |
| بيانات النشر: | Harcourt Publishers, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, obesity, Cancer Research, medicine.medical_specialty, ovarian cancer-specific survival, Epidemiology, overall survival, Kaplan-Meier Estimate, Carcinoma, Ovarian Epithelial, Disease-Free Survival, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Ovarian carcinoma, medicine, Humans, Neoplasms, Glandular and Epithelial, Progression-free survival, 030304 developmental biology, Ovarian Neoplasms, 2. Zero hunger, Gynecology, 0303 health sciences, business.industry, Hazard ratio, Cancer, medicine.disease, 3. Good health, Serous fluid, ovarian cancer, 030220 oncology & carcinogenesis, Meta-analysis, Female, business, Ovarian cancer, Body mass index, progression-free survival |
| الوصف: | © 2015 Cancer Research UK. All rights reserved. Background: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer. Methods: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype. Results: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ≥35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m -2) and endometrioid subtypes (pHR: 1.08 per 5 kg m -2), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m -2) subtype, but only the association with high-grade serous cancers was significant. Conclusions: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer. |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cf8783ff80f93fc33acf03ac3997ffTest https://lirias.kuleuven.be/handle/123456789/502695Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f3cf8783ff80f93fc33acf03ac3997ff |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |