دورية أكاديمية
Obesity, vascular disease and frailty in aging women with HIV
| العنوان: | Obesity, vascular disease and frailty in aging women with HIV |
|---|---|
| المؤلفون: | Gustafson, Deborah R., McFarlane, Samy I. |
| بيانات النشر: | Högskolan i Skövde, Institutionen för hälsovetenskaper Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering Section for NeuroEpidemiology, Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY, USA Division of Endocrinology, Department of Medicine, College of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY, USA Hapres |
| سنة النشر: | 2021 |
| المجموعة: | University of Skövde: Publications (DiVA) |
| مصطلحات موضوعية: | frailty, HIV, obesity, cardiovascular disease, aging, bone, Geriatrics, Geriatrik, Nutrition and Dietetics, Näringslära, Cardiac and Cardiovascular Systems, Kardiologi, Infectious Medicine, Infektionsmedicin, Public Health, Global Health, Social Medicine and Epidemiology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi |
| الوصف: | Women with chronic HIV infection (WWH) living in the United States, experience a disproportionately high rate of obesity compared to uninfected populations. Both overweight and obesity, particularly central obesity, are major contributors to insulin resistance, hypertension, and dyslipidemia—the major components of metabolic syndromes, including type 2 diabetes, and leading to increased cardiovascular risk, including coronary heart disease, and cerebrovascular diseases. Notably, declining physical performance and frailty co-occur with vascular morbidities as well as changes in bone. These factors tend to exacerbate each other and accelerate the aging trajectory, leading to poorer quality of life, cognitive impairments, dementia, and eventually, death. In WWH, persistent HIV infection, sustained treatment for HIV infection, and concomitant obesity, may accelerate aging-related morbidities and poorer aging outcomes. Furthermore, health disparities factors common among some WWH, are independently associated with obesity and higher vascular risk. The purpose of this review is to describe the constellation of obesity, cardio- and cerebrovascular diseases, bone health and frailty among aging WWH, a 21st century emergence. ; CC BY 4.0 Received: 23 December 2019; Accepted: 10 June 2021; Published: 22 June 2021 Correspondence: Deborah R. Gustafson This research was funded by NIH, U01-HL146202-01 and U01-AI-031834. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | 2021, 3:3; Advances in Geriatric Medicine and Research, 2021, 3:3; http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18021Test; PMID 34368807 |
| DOI: | 10.20900/agmr20210014 |
| الإتاحة: | https://doi.org/10.20900/agmr20210014Test http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18021Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCFB94C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.20900/agmr20210014 |
|---|