Imbalance of the antioxidant network of mouse small intestinal mucosa after radiation exposure
| العنوان: | Imbalance of the antioxidant network of mouse small intestinal mucosa after radiation exposure |
|---|---|
| المؤلفون: | Marc Benderitter, Céline Haton, Marie Vandamme, Agnès François, N. M. Griffiths, Julie Wysocki |
| المساهمون: | Laboratoire de Radiopathologie et Thérapies Expérimentales, Institut de Radioprotection et de Sûreté Nucléaire (IRSN) |
| المصدر: | Radiation Research Radiation Research, 2007, 167 (4), pp.445-453. ⟨10.1667/RR0581.1⟩ |
| بيانات النشر: | HAL CCSD, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Antioxidant, antioxidant, medicine.medical_treatment, [SDV]Life Sciences [q-bio], environmental exposure, antioxidant activity, radiation exposure, reactive oxygen metabolite, medicine.disease_cause, Small, Inbred C57BL, Antioxidants, chemistry.chemical_compound, Mice, 0302 clinical medicine, Intestinal mucosa, Intestine, Small, oxidative stress, animal, Intestinal Mucosa, glutathione peroxidase, enteritis, chemistry.chemical_classification, 0303 health sciences, Radiation, messenger RNA, C57BL mouse, Glutathione peroxidase, catalase, article, Environmental exposure, superoxide dismutase, 3. Good health, enzyme activity, Intestine, priority journal, 030220 oncology & carcinogenesis, intestine mucosa, mucosa inflammation, radiation dose, signal transduction, radiation injury, medicine.medical_specialty, radiation response, Biophysics, dexamethasone, protein localization, Biology, Radiation Dosage, animal tissue, Superoxide dismutase, in vivo study, Dose-Response Relationship, 03 medical and health sciences, Internal medicine, medicine, small intestine mucosa, Animals, Radiology, Nuclear Medicine and imaging, defense mechanism, Radiation Injuries, protein expression, mouse, 030304 developmental biology, Reactive oxygen species, nonhuman, Dose-Response Relationship, Radiation, nucleotide sequence, Glutathione, thioredoxin, metallothionein, Mice, Inbred C57BL, Endocrinology, chemistry, inflammation, protein analysis, Immunology, biology.protein, pathology, Reactive Oxygen Species, metabolism, small intestine, Oxidative stress |
| الوصف: | The aim of this study was to investigate acute variations in antioxidant defense systems in the intestinal mucosa after abdominal radiation exposure and the role played by radiation-induced inflammation in these variations. Antioxidant defense systems of mouse small intestinal mucosa were studied at 6 h and 4 days after abdominal radiation exposure. Superoxide dismutases, glutathione peroxidases, catalase, metallothioneins and thioredoxins were followed in terms of mRNA expression, protein expression and enzyme activities. Dexamethasone was administered to investigate the relationship between variations in mucosal antioxidant capacity and radiation-induced inflammation. Six hours after exposure, only mitochondrial-associated antioxidant systems were induced (the superoxide dismutase and thioredoxin 2). Four days after exposure, during the inflammatory phase, superoxide dismutases were decreased and modulations of the second line of the antioxidant network were also observed: Catalase was decreased and glutathione peroxidases and metallothioneins were induced. Dexamethasone treatment modulated only glutathione peroxidase expression and did not influence either metallothionein or superoxide dismutase expression. Our findings provide direct in vivo evidence that antioxidant mechanisms of the small intestinal mucosa were not markedly mobilized during the very acute tissue radiation response. During the radiation-induced acute inflammatory response, the antioxidant capacity appeared to be dependent on inflammatory status to a certain extent. © 2007 by Radiation Research Society. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90aa5bffa86ce5f1b63af6690db79b9Test https://hal.archives-ouvertes.fr/hal-03008511Test |
| رقم الانضمام: | edsair.doi.dedup.....b90aa5bffa86ce5f1b63af6690db79b9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |