التفاصيل البيبلوغرافية
| العنوان: |
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways |
| المؤلفون: |
O'Dushlaine, C., Rossin, L., Lee P., H., Duncan, L., Parikshak N., N., Newhouse, S., Ripke, S., Neale B., M., Purcell S., M., Posthuma, D., Nurnberger J., I., Lee S., H., Faraone S., V., Perlis R., H., Mowry B., J., Thapar, A., Goddard M., E., Witte J., S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen O., A., Anjorin, A., Anney, R., Anttila, V., Arking D., E., Asherson, P., Azevedo M., H., Backlund, L., Badner J., A., Bailey A., J., Banaschewski, T., Barchas J., D., Barnes M., R., Barrett T., B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen S., E., Berrettini, W., Betancur, Catalina, Bettecken, T., Biederman, J., Binder E., B., Black D., W., Blackwood D., H., Bloss C., S., Boehnke, M., Boomsma D., I., Breuer, R., Bruggeman, R., Cormican, P., Buccola N., G., Buitelaar J., K., Bunney W., E., Buxbaum J., D., Byerley W., F., Byrne E., M., Caesar, S., Cahn, W., Cantor R., M., Casas, M., Chakravarti, A., Chambert, K., Choudhury, K., Cichon, S., Mattheisen, M., Cloninger C., R., Collier D., A., Cook E., H., Coon, H., Cormand, B., Corvin, A., Coryell W., H., Craig D., W., Craig I., W., Crosbie, J., Cuccaro M., L., Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., de Geus E., J., Degenhardt, F., Djurovic, S., Donohoe G., J., Doyle A., E., Duan, J., Dudbridge, F., Duketis, E., Ebstein R., P., Edenberg H., J., Elia, J., Ennis, S., Etain, B., Fanous, F., Farmer, A., Ferrier I., N., Flickinger, M., Fombonne, E., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer N., B., Freitag C., M., Friedl, M., Frisén, L., Gallagher, L., Gejman P., V., Georgieva, L., Gershon E., S., Giegling, I., Gill, M., Gordon S., D., Gordon-Smith, K., Green E., K., Greenwood T., A., Grice D., E., Gross, M., Grozeva, D., Guan, W., Gurling, H., de Haan, L., Haines, J., Hakonarson, H., Hallmayer, J., Hamilton S., P., Hamshere M., L., Hansen T., F., Hartmann A., M., Hautzinger, M., Heath A., C., Henders A., K., Herms, S., Hickie I., B., Hipolito, M., Hoefels, S., Holsboer, F., Hoogendijk W., J., Hottenga J., J., Hultman C., M., Hus, V., Ingason, A., Ising, M., Jamain, S., Jones E., G., Jones, I., Jones, L., Tzeng J., Y., Kähler, A., Kahn R., S., Kandaswamy, R., Keller M., C., Kennedy J., L., Kenny, E., Kent, L., Kim, Y., Kirov G., K., Klauck S., M., Klei, L., Knowles J., A., Kohli, M.A., Koller, D., Konte, B., Korszun, A., Krabbendam, L., Krasucki, R., Kuntsi, J., Kwan, P., Landén, M., Längström, N., Lathrop, M., Lawrence, J., Lawson W., B., Leboyer, M., Ledbetter D., H., Lencz, T., Lesch K., P., Levinson D., F., Lewis C., M., Li, J., Lichtenstein, P., Lieberman J., A., Lin D., Y., Linszen D., H., Liu, C., Lohoff F., W., Loo S., K., Lord, C., Lowe J., K., Lucae, S., Macintyre D., J., Madden P., A., Maestrini, E., Magnusson P., K., Mahon P., B., Maier, W., Malhotra A., K., Mane S., M., Martin C., L., Martin N., G., Matthews, K., Mattingsdal, M., Mccarroll S., A., Mcghee K., A., Mcgough J., J., Mcgrath P., J., Mcguffin, P., Mcinnis M., G., Mcintosh, A., Mckinney, R., Mclean A., W., Mcmahon F., J., Mcmahon W., M., Mcquillin, A., Medeiros, H., Medland S., E., Meier, S., Melle, I., Meyer, J., Middeldorp C., M., Middleton, L., Milanova, V., Miranda, A., Monaco A., P., Montgomery G., W., Moran J., L., Moreno-De-Luca, D., Morken, G., Morris D., W., Morrow E., M., Moskvina, V., Muglia, P., Mühleisen T., W., Muir W., J., Müller-Myhsok, B., Murtha, M., Myers R., M., Myin-Germeys, I., Neale M., C., Nelson S., F., Nievergelt C., M., Nikolov, I., Nimgaonkar, V., Nolen W., A., Nöthen M., M., Nwulia E., A., Nyholt D., R., Oades R., D., Olincy, A., Oliveira, G., Olsen, L., Ophoff R., A., Osby, U., Owen M., J., Palotie, A., Parr J., R., Paterson A., D., Pato C., N., Pato M., T., Penninx B., W., Pergadia M., L., Pericak-Vance M., A., Pickard B., S., Pimm, J., Piven, J., Potash J., B., Poustka, F., Propping, P., Puri, V., Quested D., J., Quinn E., M., Ramos-Quiroga J., A., Rasmussen H., B., Raychaudhuri, S., Rehnström, K., Reif, A., Ribasés, M., Rice J., P., Rietschel, M., Roeder, K., Roeyers, H., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders A., R., Sanders S., J., Santangelo S., L., Sergeant J., A., Schachar, R., Schalling, M., Schatzberg A., F., Scheftner W., A., Schellenberg G., D., Scherer S., W., Schork N., J., Schulze T., G., Schumacher, J., Schwarz, M., Scolnick, E., Scott L., J., Shi, J., Shilling P., D., Shyn S., I., Silverman J., M., Slager S., L., Smalley S., L., Smit J., H., Smith E., N., Sonuga-Barke E., J., St Clair, D., State, M., Steffens, M., Steinhausen H., C., Strauss J., S., Strohmaier, J., Stroup T., S., Sutcliffe J., S., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson R., C., Todorov A., A., Tozzi, F., Treutlein, J., Uhr, M., van den Oord J., C., van Grootheest, G., van Os, J., Vicente A., M., Vieland V., J., Vincent J., B., Visscher P., M., Walsh C., A., Wassink, T., Watson, S., Weissman M., M., Werge, T., Wienker T., F., Wijsman E., M., Willemsen, G., Williams, N., Willsey A., J., Witt S., H., Xu, Wei-Jiang, Young A., H., Yu T., W., Zammit, S., Zandi P., P., Zhang, P., Zitman F., G., Zöllner, S., Devlin, B., Kelsoe J., R., Sklar, P., Daly M., J., O'Donovan M., C., Craddock, N., Kendler K., S., Weiss L., A., Wray N., R., Zhao, Z., Geschwind D., H., Sullivan P., F., Smoller J., W., Holmans P., A., Breen, G. |
| المساهمون: |
Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: |
ISSN: 1097-6256. |
| بيانات النشر: |
HAL CCSD
Nature Publishing Group |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Depression, Genome-wide association studies, Schizophrenia, Statistical methods, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: |
International audience ; Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
hal-01548830; https://hal.sorbonne-universite.fr/hal-01548830Test |
| DOI: |
10.1038/nn.3922 |
| الإتاحة: |
https://doi.org/10.1038/nn.3922Test
https://hal.sorbonne-universite.fr/hal-01548830Test |
| رقم الانضمام: |
edsbas.D6D10ED9 |
| قاعدة البيانات: |
BASE |
