دورية أكاديمية
Alterations in gene expression and a Scandinavian multiple sclerosis association study of the SNP rs4763655
| العنوان: | Alterations in gene expression and a Scandinavian multiple sclerosis association study of the SNP rs4763655 |
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| المؤلفون: | Søndergaard, Helle Bach, Sellebjerg, Finn, Hillert, Jan, Olsson, Tomas, Kockum, Ingrid, Lindén, Magdalena, Mero, Inger-Lise, Myhr, Kjell-Morten, Celius, Elisabeth Gulowsen, Harbo, Hanne Flinstad, Christensen, Jeppe Romme, Börnsen, Lars, Soelberg Sorensen, Per, Oturai, Annette Bang |
| المساهمون: | Dept. of Neurology, University Hospital Rigshospitalet |
| المصدر: | ISSN: 1018-4813. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2011 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | KLRB1, multiple sclerosis, CD161 |
| الوصف: | International audience ; Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes, among these the gene, represented by the single nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (p=0.046, OR=1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of in blood from MS patients was higher compared with healthy controls (p<0.001), and the expression decreased significantly (p<0.001) after interferon-β treatment. was expressed in T cells and NK cells, and expression mainly decreased in NK cells in patients treated with interferon-b. Collectively our results indicate that gene expression is altered in MS and likely to be involved in the pathogenesis of the disease, whereas rs4763655 in seems to play a minimal role in MS susceptibility. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00644721; https://hal.archives-ouvertes.fr/hal-00644721Test; https://hal.archives-ouvertes.fr/hal-00644721/documentTest; https://hal.archives-ouvertes.fr/hal-00644721/file/PEER_stage2_10.1038%252Fejhg.2011.88.pdfTest |
| DOI: | 10.1038/ejhg.2011.88 |
| الإتاحة: | https://doi.org/10.1038/ejhg.2011.88Test https://hal.archives-ouvertes.fr/hal-00644721Test https://hal.archives-ouvertes.fr/hal-00644721/documentTest https://hal.archives-ouvertes.fr/hal-00644721/file/PEER_stage2_10.1038%252Fejhg.2011.88.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.9D7612FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ejhg.2011.88 |
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