Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock
| العنوان: | Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock |
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| المؤلفون: | Sandrine Marchand, A Tikkerberi, Juri Karjagin, Ronald J. Sawchuk, Joel Starkopf, S Lefeuvre, William Couet, Kersti Oselin, Karin Kipper |
| المساهمون: | Clinics of Anaesthesiology and Intensive Care, University Clinics of Tartu, Modélisations pharmacocinétiques-pharmacodynamiques pour un meilleur usage des anti-infectieux, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Poitiers, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Department of Pharmacology, University of Tartu, Department of Pharmaceutics, College of Pharmacy, University of Minnesota |
| المصدر: | Clinical Pharmacology and Therapeutics Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2007, 83 (3), pp.452-459. ⟨10.1038/sj.clpt.6100312⟩ |
| بيانات النشر: | HAL CCSD, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Microdialysis, [SDV]Life Sciences [q-bio], Peritonitis, Gastroenterology, Meropenem, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Ascitic Fluid, Humans, Pharmacology (medical), Tissue Distribution, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Antibacterial agent, Aged, Pharmacology, Aged, 80 and over, 0303 health sciences, 030306 microbiology, Septic shock, business.industry, Peritoneal fluid, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, medicine.disease, Shock, Septic, Surgery, Anti-Bacterial Agents, Shock (circulatory), Female, Thienamycins, medicine.symptom, business, medicine.drug |
| الوصف: | Our objective was to describe the pharmacokinetics of meropenem in the peritoneal fluid (PF) of six patients with severe peritonitis and septic shock and to relate measured concentrations to the minimum inhibitory concentration of bacteria. Microdialysis catheters were placed into the peritoneal space during surgery. Meropenem concentrations in plasma and in PF were analyzed using compartmental modeling. Meropenem areas under the concentration-time curve were lower in PF than in plasma (average ratio, 73.8+/-15%) because of degradation confirmed ex vivo. Compartment modeling with elimination from a peripheral compartment described the data adequately, and was used to simulate steady-state concentration profiles in plasma and PF during various dosing regimens. At the currently recommended dosing regimen of 1 g infused over 20 min every 8 h, PF concentrations of meropenem in patients with severe peritonitis associated with septic shock reach values sufficient for antibacterial effects against susceptible, but not always against intermediately susceptible, bacteria. |
| اللغة: | English |
| تدمد: | 0009-9236 1532-6535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbf19d4809607709a540c47a420cb60Test https://hal.archives-ouvertes.fr/hal-02463154Test |
| رقم الانضمام: | edsair.doi.dedup.....6fbf19d4809607709a540c47a420cb60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00099236 15326535 |
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