LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation
| العنوان: | LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation |
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| المؤلفون: | Constance Ciaudo, Jacob L. Glass, Jennifer C. Chow, Matthew Attreed, Nicolas Servant, Anton Wutz, Philip Avner, Edith Heard, Nathan Mise, Melissa Fazzari, John M. Greally, Olivier Voinnet, Emmanuel Barillot |
| المساهمون: | Génétique et Biologie du Développement, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Albert Einstein College of Medicine [New York], Génétique des Déficits sensoriels, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Jichi Medical University, Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe, MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Cambridge [UK] (CAM), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Jichi Medical University [Tochigi-Ken, Japan], Mines Paris - PSL (École nationale supérieure des mines de Paris), Institut Curie [Paris]-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Cell Cell, Elsevier, 2010, 141 (6), pp.956-969. ⟨10.1016/j.cell.2010.04.042⟩ Cell, 2010, 141 (6), pp.956-969. ⟨10.1016/j.cell.2010.04.042⟩ |
| بيانات النشر: | HAL CCSD, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | 0301 basic medicine, RNA, Untranslated, Transcription, Genetic, DEVBIO, MESH: RNA, Untranslated, chemistry.chemical_compound, Mice, 0302 clinical medicine, Transcription (biology), X Chromosome Inactivation, Heterochromatin, MESH: Animals, MESH: Embryonic Stem Cells, X chromosome, Genetics, 0303 health sciences, MESH: X Chromosome Inactivation, Cell biology, MESH: Heterochromatin, MESH: RNA, Long Noncoding, Female, RNA, Long Noncoding, X Chromosome, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, General Biochemistry, Genetics and Molecular Biology, X-inactivation, Cell Line, 03 medical and health sciences, Animals, Humans, Gene, MESH: Mice, Embryonic Stem Cells, 030304 developmental biology, MESH: Long Interspersed Nucleotide Elements, MESH: X Chromosome, MESH: Humans, Biochemistry, Genetics and Molecular Biology(all), MESH: Transcription, Genetic, RNA, DNA, MESH: Cell Line, 030104 developmental biology, Long Interspersed Nucleotide Elements, chemistry, XIST, MESH: Female, 030217 neurology & neurosurgery |
| الوصف: | International audience; During X chromosome inactivation (XCI), Xist RNA coats and silences one of the two X chromosomes in female cells. Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show that LINEs participate in creating a silent nuclear compartment into which genes become recruited. A subset of young LINE-1 elements, however, is expressed during XCI, rather than being silenced. We demonstrate that such LINE expression requires the specific heterochromatic state induced by Xist. These LINEs often lie within escape-prone regions of the X chromosome, but close to genes that are subject to XCI, and are associated with putative endo-siRNAs. LINEs may thus facilitate XCI at different levels, with silent LINEs participating in assembly of a heterochromatic nuclear compartment induced by Xist, and active LINEs participating in local propagation of XCI into regions that would otherwise be prone to escape. |
| اللغة: | English |
| تدمد: | 0092-8674 1097-4172 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2a00db3b00403c61dfbcf871ba8012Test https://hal.archives-ouvertes.fr/hal-00508558Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea2a00db3b00403c61dfbcf871ba8012 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00928674 10974172 |
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