دورية أكاديمية
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
| العنوان: | Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments |
|---|---|
| المؤلفون: | Genet, Martin, Lee, Lik Chuan, Nguyen, Rebecca, Haraldsson, Henrik, Acevedo-Bolton, Gabriel, Zhang, Zhihong, Ge, Liang, Ordovas, Karen, Kozerke, Sebastian, Guccione, Julius M. |
| المساهمون: | University of California San Francisco (UC San Francisco), University of California (UC), Veterans Affairs Medical Center, San Francisco, California, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology Zürich (ETH Zürich) |
| المصدر: | ISSN: 8750-7587. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2014 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] |
| الوصف: | International audience ; Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human heart, including ventricular remodeling, which is frequently associated with heart failure. Therefore, normalization of ventricular wall stress is the cornerstone of many existing and new treatments for heart failure. In this paper, we sought to construct reference maps of normal ventricular wall stress in humans that could be used as a target for in silico optimization studies of existing and potential new treatments for heart failure. To do so, we constructed personalized computational models of the left ventricles of five normal human subjects using magnetic resonance images and the finite-element method. These models were calibrated using left ventricular volume data extracted from magnetic resonance imaging (MRI) and validated through comparison with strain measurements from tagged MRI (950 ± 170 strain comparisons/subject). The calibrated passive material parameter values were C0 = 0.115 ± 0.008 kPa and B0 = 14.4 ± 3.18; the active material parameter value was Tmax = 143 ± 11.1 kPa. These values could serve as a reference for future construction of normal human left ventricular computational models. The differences between the predicted and the measured circumferential and longitudinal strains in each subject were 3.4 ± 6.3 and 0.5 ± 5.9%, respectively. The predicted end-diastolic and end-systolic myofiber stress fields for the five subjects were 2.21 ± 0.58 and 16.54 ± 4.73 kPa, respectively. Thus these stresses could serve as targets for in silico design of heart failure treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01196388; https://hal.science/hal-01196388Test; PUBMEDCENTRAL: PMC4101610 |
| DOI: | 10.1152/japplphysiol.00255.2014 |
| الإتاحة: | https://doi.org/10.1152/japplphysiol.00255.2014Test https://hal.science/hal-01196388Test |
| رقم الانضمام: | edsbas.393BB245 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/japplphysiol.00255.2014 |
|---|