دورية أكاديمية
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
| العنوان: | Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial. |
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| المؤلفون: | Gounder, M. M., Razak, A. A., Somaiah, N., Chawla, S., Martin-Broto, J., Grignani, G., Schuetze, S. M., Vincenzi, B., Wagner, A. J., Chmielowski, B., Jones, R. L., Riedel, R. F., Stacchiotti, S., Loggers, E. T., Ganjoo, K. N., Le Cesne, A., Italiano, A., Garcia del Muro, X., Burgess, M., Piperno-Neumann, S., Ryan, C., Mulcahy, M. F., Forscher, C., Penel, Nicolas, Okuno, S., Elias, A., Hartner, L., Philip, T., Alcindor, T., Kasper, B., Reichardt, P., Lapeire, L., Blay, J. Y., Chevreau, C., Valverde Morales, C. M., Schwartz, G. K., Chen, J. L., Deshpande, H., Davis, E. J., Nicholas, G., Gröschel, S., Hatcher, H., Duffaud, F., Herráez, A. C., Beveridge, R. D., Badalamenti, G., Eriksson, M., Meyer, C., von Mehren, M., van Tine, B. A., Götze, K., Mazzeo, F., Yakobson, A., Zick, A., Lee, A., Gonzalez, A. E., Napolitano, A., Dickson, M. A., Michel, D., Meng, C., Li, L., Liu, J., Ben-Shahar, O., van Domelen, D. R., Walker, C. J., Chang, H., Landesman, Y., Shah, J. J., Shacham, S., Kauffman, M. G., Attia, S. |
| المساهمون: | Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| المصدر: | ISSN: 0732-183X. |
| بيانات النشر: | HAL CCSD American Society of Clinical Oncology |
| سنة النشر: | 2022 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; PurposeAntitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.MethodsSEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of study treatment were included for safety analysis (ClinicalTrials.gov identifier: NCT02606461).ResultsTwo hundred eighty-five patients were enrolled (selinexor, n = 188; placebo, n = 97). PFS was significantly longer with selinexor versus placebo: hazard ratio (HR) 0.70 (95% CI, 0.52 to 0.95; one-sided P = .011; medians 2.8 v 2.1 months), as was time to next treatment: HR 0.50 (95% CI, 0.37 to 0.66; one-sided P < .0001; medians 5.8 v 3.2 months). With crossover, no difference was observed in overall survival. The most common treatment-emergent adverse events of any grade versus grade 3 or 4 with selinexor were nausea (151 [80.7%] v 11 [5.9]), decreased appetite (113 [60.4%] v 14 [7.5%]), and fatigue (96 [51.3%] v 12 [6.4%]). Four (2.1%) and three (3.1%) patients died in the selinexor and placebo arms, respectively. Exploratory RNA sequencing analysis identified that the absence of CALB1 expression was associated with longer PFS with selinexor compared with placebo (median 6.9 v 2.2 months; HR, 0.19; P = .001).ConclusionPatients with advanced, refractory DD-LPS showed improved PFS and time to next treatment with selinexor compared with placebo. Supportive care and dose reductions mitigated side effects of selinexor. Prospective validation of CALB1 expression as a predictive biomarker for selinexor in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35394800; hal-04562855; https://hal.univ-lille.fr/hal-04562855Test; PUBMED: 35394800 |
| DOI: | 10.1200/JCO.21.01829 |
| الإتاحة: | https://doi.org/10.1200/JCO.21.01829Test https://hal.univ-lille.fr/hal-04562855Test |
| رقم الانضمام: | edsbas.454F51F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1200/JCO.21.01829 |
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