The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma
| العنوان: | The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma |
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| المؤلفون: | Franco Roviello, Paul M. Schneider, Fátima Carneiro, Christoph Röcken, William H. Allum, Florian Lordick, Marcel Verheij, Guillaume Piessen, Antoine Adenis, Manfred P. Lutz, Heike I. Grabsch, Elizabeth C Smyth, Michel Ducreux, Stefan Seewald, Pierre Laurent-Puig, John Zalcberg, Anna Dorothea Wagner, Markus Möhler, Angela Riddell, Eric Van Cutsem, Florian Otto, Daniela Aust, Stefan Mönig, Radka Obermannova |
| المساهمون: | Monash University [Melbourne], Institut Gustave Roussy (IGR), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Royal Marsden NHS Foundation Trust, Cambridge University Hospitals - NHS (CUH), University of Cambridge [UK] (CAM), Institut für Pathologie [Berlin], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto = University of Porto, Faculdade de Medicina da Universidade do Porto (FMUP), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Université Paris Descartes - Paris 5 (UPD5), University Hospital Leipzig, University Medical Center [Mainz], Hôpitaux Universitaires de Genève (HUG), Masaryk Memorial Cancer Institute (MMCI), Université de Lille, The Royal Marsden, Christian-Albrechts University of Kiel, Università degli Studi di Siena = University of Siena (UNISI), University Hospital Gasthuisberg [Leuven], Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Brustzentrum Kantonsspital St. Gallen, Universidade do Porto, Masaryk Memorial Cancer Institute (RECAMO), University Hospital Gasthuisberg, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Universidade do Porto [Porto], Faculdade de Medicina da Universidade do Porto [Porto] (FMUP), Maastricht University Medical Center (MUMC), Università degli Studi di Siena (UNISI) |
| المصدر: | European Journal of Cancer European Journal of Cancer, 2019, 112, pp.1-8. ⟨10.1016/j.ejca.2019.01.106⟩ European Journal of Cancer, 112, 1-8 European Journal of Cancer, Elsevier, 2019, 112, pp.1-8. ⟨10.1016/j.ejca.2019.01.106⟩ European Journal of Cancer, 112, pp. 1-8 |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Endoscopic ultrasound, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Adenocarcinoma of the gastro-oesophageal junction, Expert consensus, Gastric cancer, Multimodal treatment, SURGERY, [SDV]Life Sciences [q-bio], Adenocarcinoma, DECISION-MAKING, DIAGNOSIS, CHEMORADIOTHERAPY, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Gastrointestinal cancer, the gastro-oesophageal junction, medicine.diagnostic_test, PERIOPERATIVE CHEMOTHERAPY, GASTROESOPHAGEAL ADENOCARCINOMA, Perioperative, medicine.disease, Combined Modality Therapy, Neoadjuvant Therapy, 3. Good health, Oxaliplatin, PATHOLOGY, Regimen, 030104 developmental biology, Oncology, Docetaxel, Fluorouracil, 030220 oncology & carcinogenesis, SURVIVAL, Esophagogastric Junction, CLINICAL-PRACTICE GUIDELINES, Radiology, Adenocarcinoma of, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], medicine.drug |
| الوصف: | Contains fulltext : 207090.pdf (Publisher’s version ) (Closed access) Multimodal primary treatment of localised adenocarcinoma of the stomach, the oesophagus and the oesophagogastric junction (AEG) was reviewed by a multidisciplinary expert panel in a moderated consensus session. Here, we report the key points of the discussion and the resulting recommendations. The exact definition of the tumour location and extent by white light endoscopy in conjunction with computed tomography scans is the backbone for any treatment decision. Their value is limited with respect to the infiltration depth, lymph node involvement and peritoneal involvement. Additional endoscopic ultrasound was recommended mainly for tumours of the lower oesophagogastric junction (i.e. AEG type II and III according to Siewert) and in early cancers before endoscopic resection. Laparoscopy to diagnose peritoneal involvement was thought to be necessary before the start of neoadjuvant treatment in all gastric cancers and in AEG type II and III. In general, perioperative multimodal treatment was suggested for all locally advanced oesophageal tumours and for gastric cancers with a clinical stage above T1N0. There was consensus that the combination of fluorouracil, folinic acid, oxaliplatin and docetaxel is now a new standard chemotherapy (CTx) regimen for fit patients. In contrast, the optimal choice of perioperative CTx versus neoadjuvant radiochemotherapy (neoRCTx), especially for AEG, was identified as an open question. Expert treatment recommendations depend on the tumour location, biology, the risk of incomplete (R1) resection, response to treatment, local or systemic recurrence risks, the predicted perioperative morbidity and patients' comorbidities. In summary, any treatment decision requires an interdisciplinary discussion in a comprehensive multidisciplinary setting. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0959-8049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4a5289edb8e9461b809c98ace27a7fTest https://hal.umontpellier.fr/hal-02466817Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb4a5289edb8e9461b809c98ace27a7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09598049 |
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