دورية أكاديمية
Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila
| العنوان: | Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila |
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| المؤلفون: | Perez-Mockus, Gantas, Mazouni, Khalil, Roca, Vanessa, Corradi, Giulia, Conte, Vito, Schweisguth, François |
| المساهمون: | Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Cellule Pasteur UPMC, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur Paris (IP), Génétique Moléculaire des Virus Respiratoires, Institut Pasteur Paris (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Bioenginyeria de Catalunya, ICREA (IBEC), Universitat de Barcelona (UB)-Facultat de Medicina |
| المصدر: | ISSN: 2041-1723. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Embryo-scale morphogenesis arises from patterned mechanical forces. During Drosophila gastrulation, actomyosin contractility drives apical constriction in ventral cells, leading to furrow formation and mesoderm invagination. It remains unclear whether and how mechanical properties of the ectoderm influence this process. Here, we show that Neuralized (Neur), an E3 ubiquitin ligase active in the mesoderm, regulates collective apical constriction and furrow formation. Conversely, the Bearded (Brd) proteins antagonize maternal Neur and lower medial–apical contractility in the ectoderm: in Brd-mutant embryos, the ventral furrow invaginates properly but rapidly unfolds as medial MyoII levels increase in the ectoderm. Increasing contractility in the ectoderm via activated Rho similarly triggers furrow unfolding whereas decreasing contractility restores furrow invagination in Brd-mutant embryos. Thus, the inhibition of Neur by Brd in the ectoderm differentiates the mechanics of the ectoderm from that of the mesoderm and patterns the activity of MyoII along the dorsal–ventral axis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29150614; hal-01654643; https://hal.sorbonne-universite.fr/hal-01654643Test; https://hal.sorbonne-universite.fr/hal-01654643/documentTest; https://hal.sorbonne-universite.fr/hal-01654643/file/s41467-017-01482-8.pdfTest; PUBMED: 29150614 |
| DOI: | 10.1038/s41467-017-01482-8 |
| الإتاحة: | https://doi.org/10.1038/s41467-017-01482-8Test https://hal.sorbonne-universite.fr/hal-01654643Test https://hal.sorbonne-universite.fr/hal-01654643/documentTest https://hal.sorbonne-universite.fr/hal-01654643/file/s41467-017-01482-8.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E6870848 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-017-01482-8 |
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