Circulating innate immune markers and outcomes in treatment-naïve advanced non–small cell lung cancer patients
| العنوان: | Circulating innate immune markers and outcomes in treatment-naïve advanced non–small cell lung cancer patients |
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| المؤلفون: | Benjamin Besse, Lydie Cassard, David Planchard, B. Duchemann, Sylvie Rusakiewicz, Caroline Caramella, M. Charrier, Louise Dupraz, Nathalie Chaput, Jordi Remon, Roberto Ferrara, L. Boselli, E. Pogge von Strandmann, Béranger Lueza, Jean-Pierre Pignon, Katrin S Reiners, Laura Mezquita, M. Naigeon |
| المساهمون: | Département d'hématologie [Gustave Roussy], Institut Gustave Roussy (IGR), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay |
| المصدر: | European Journal of Cancer European Journal of Cancer, Elsevier, 2019, 108, pp.88-96. ⟨10.1016/j.ejca.2018.12.017⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Lung Neoplasms, Neutrophils, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Peripheral blood mononuclear cell, Monocytes, 03 medical and health sciences, Leukocyte Count, 0302 clinical medicine, Immune system, Monocytosis, Carcinoma, Non-Small-Cell Lung, medicine, Humans, RNA, Messenger, Lung cancer, 030304 developmental biology, Aged, Proportional Hazards Models, Aged, 80 and over, 0303 health sciences, Chemotherapy, Innate immune system, Natural Cytotoxicity Triggering Receptor 3, L-Lactate Dehydrogenase, business.industry, Monocyte, Middle Aged, medicine.disease, Prognosis, Neutrophilia, Immunity, Innate, Progression-Free Survival, 3. Good health, Killer Cells, Natural, Survival Rate, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunology, Female, medicine.symptom, business, Molecular Chaperones |
| الوصف: | Introduction Innate immunity represents the first step of activation of the immune system and dictates the quality of adaptive immune responses. Studies have reported links between systemic inflammatory or innate immune markers and prognosis in patients with lung cancer. To our knowledge, the prospective and concomitant study of these systemic markers has never been performed. Methods Advanced treatment-naive non–small cell lung cancer (NSCLC) patients eligible for first-line platinum-based chemotherapy were prospectively included from December 2012 to July 2015 (N = 148). Blood samples of patients were collected before the first cycle for fresh NK cell phenotyping. Peripheral blood mononuclear cells were cryopreserved for natural cytotoxicity receptor (NCR) genotyping as well as sera for NCR's ligand quantification. Data on leukocytes, neutrophils and monocyte counts and lactate dehydrogenase (LDH) levels were extracted from electronic medical records. Results Among all studied markers, monocytosis, neutrophilia, leucocytosis, high LDH and sBAG6 levels and reduced levels of NCR3 transcripts were associated with poor overall survival (OS) in univariate analysis. The levels of NCR3 transcripts was linked to age, number of metastatic sites, monocyte counts, LDH and sBAG6 levels. Neutrophilia was associated to high sBAG6 levels. NCR3 was the unique innate immune parameter that remained as an independent factor associated with both OS (P = 0.003) and progression-free survival (P = 0.009) in the multivariate analysis. Conclusion This study brought evidence that these biomarkers are entangled; parameters associated with an inflammatory process were related to reduced levels of NCR3 transcripts. Finally, the level of NCR3 transcripts was independently associated with outcomes in treatment-naive patients with advanced NSCLC. |
| اللغة: | English |
| تدمد: | 0959-8049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d354619b6829bdc2c9acd50d613ca6Test https://hal.archives-ouvertes.fr/hal-03486166Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3d354619b6829bdc2c9acd50d613ca6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09598049 |
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