المؤلفون: Krieger, Viktoria, Hamacher, Alexandra, Gertzen, Christoph, Senger, Johanna, Zwinderman, Martijn, Marek, Martin, Romier, Christophe, Dekker, Frank, Kurz, Thomas, Jung, Manfred, Gohlke, Holger, Kassack, Matthias, Hansen, Finn

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medical Chemistry ; https://hal.science/hal-03682266Test ; Journal of Medical Chemistry, 2017, 60 (13), pp.5493-5506. ⟨10.1021/acs.jmedchem.7b00197⟩ ; http://www.ncbi.nlm.nih.gov/pubmed/28574690Test

مصطلحات موضوعية: Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Cell Line, Tumor, Cell Proliferation/drug effects, Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Histone Deacetylases/*metabolism, Humans, Models, Molecular, Molecular Structure, Peptoids/chemical synthesis/chemistry/*pharmacology, Small Molecule Libraries/chemical synthesis/chemistry/*pharmacology, Structure-Activity Relationship, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

العلاقة: hal-03682266; https://hal.science/hal-03682266Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.7b00197Test
https://hal.science/hal-03682266Test

المؤلفون: Stenzel, Katharina, Hamacher, Alexandra, Hansen, Finn, Gertzen, Christoph, Senger, Johanna, Marquardt, Viktoria, Marek, Linda, Marek, Martin, Romier, Christophe, Remke, Marc, Jung, Manfred, Gohlke, Holger, Kassack, Matthias, Kurz, Thomas

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0022-2623.

مصطلحات موضوعية: Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Histone Deacetylases/*metabolism, Humans, Molecular Docking Simulation, Molecular Structure, Structure-Activity Relationship, Antineoplastic Agents/chemistry/*pharmacology, Apoptosis/drug effects, Cell Line, Tumor, Cell Proliferation/drug effects, Cisplatin/chemistry/*pharmacology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

العلاقة: hal-03691179; https://hal.science/hal-03691179Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b01538Test
https://hal.science/hal-03691179Test

المؤلفون: Finn K. Hansen, Christophe Romier, Linda Marek, Martin Marek, Manfred Jung, Christoph G. W. Gertzen, Johanna Senger, Katharina Stenzel, Viktoria Marquardt, Marc Remke, Thomas Kurz, Alexandra Hamacher, Holger Gohlke, Matthias U. Kassack

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩

مصطلحات موضوعية: 0301 basic medicine, Histone Deacetylases/*metabolism, Antineoplastic Agents, Apoptosis, Pharmacology, Drug Screening Assays, Cisplatin/chemistry/*pharmacology, Histone Deacetylases, Cell Line, Dose-Response Relationship, Cell Proliferation/drug effects, 03 medical and health sciences, Structure-Activity Relationship, Antineoplastic Agents/chemistry/*pharmacology, Cell Line, Tumor, Drug Discovery, medicine, Urea, Structure–activity relationship, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Cell Proliferation, Cisplatin, Tumor, Dose-Response Relationship, Drug, Molecular Structure, Cell growth, Chemistry, Apoptosis/drug effects, HDAC8, Antitumor, Squamous carcinoma, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Cell culture, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Drug, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae45bc45d6f85c20596af1b3e2cbe58Test
https://hal.archives-ouvertes.fr/hal-03691179Test

المؤلفون: Judit Ovádi, Claudia A. Simões-Pires, Attila Lehotzky, Alessandra Nurisso, Philippe Bertrand, Muriel Cuendet, Nadine Martinet, Samuel Bouchet, Vincent Zwick, Christophe Blanquart

المساهمون: School of Pharmaceutical Sciences, Université de Lausanne (UNIL)-University of Geneva [Switzerland], Réseau épigénétique, Cancéropôle Grand-Ouest, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institute of Enzymology [Budapest], Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Authors thank the Centre National de la Recherche Scientifique– France, University of Poitiers, Region Poitou-Charentes (S.B. financial support), the Ligue Contre le Cancer: Committees of Vendée, et Charente-Maritime – France, ARSMeso44 – France, COST Actions CM1406 and CM1106 – Belgium and Hungarian OTKA Founds K-101039 and K-112144 for financial support. A.N. thanks the Excellence programme of the University of Geneva –Switzerland for financial support., Bernardo, Elizabeth, Université de Lausanne = University of Lausanne (UNIL)-Université de Genève = University of Geneva (UNIGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS)

المصدر: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic and Medicinal Chemistry Letters, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 1 (2016) pp. 154-159

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Intrinsic activity, Formic Acid Esters, Stereochemistry, Clinical Biochemistry, Convergent synthesis, Pharmaceutical Science, [SDV.CAN]Life Sciences [q-bio]/Cancer, Alkenes, Hydroxamic Acids, Metathesis, Biochemistry, Histone Deacetylases, Catalysis, Dose-Response Relationship, Formic Acid Esters/chemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, [SDV.CAN] Life Sciences [q-bio]/Cancer, Models, Drug Discovery, Humans, Structure–activity relationship, Benzamides/chemistry, Benzamide, Molecular Biology, ddc:615, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, Molecular, Alkenes/chemistry, 3. Good health, Histone Deacetylase Inhibitors, 030104 developmental biology, Tubulin, Histone Deacetylase Inhibitors/chemistry/pharmacology, Hydroxamic Acids/chemistry, chemistry, Benzamides, biology.protein, Molecular Medicine, Histone Deacetylases/metabolism, Drug, Selectivity

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc9fefa73c13b45a09cef22d951db0cTest
https://www.hal.inserm.fr/inserm-01299475/documentTest

المؤلفون: Zerzaihi, O., Chriett, S., Vidal, Hubert, Pirola, L.

المساهمون: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: ISSN: 0829-8211.

مصطلحات موضوعية: Promoter Regions, Genetic, Humans, Animals, Rats, Acetylation, Gene Expression Regulation, Transcription Initiation Site, Class Ia Phosphatidylinositol 3-Kinase/metabolism, Hexokinase/metabolism, Histone Deacetylases/metabolism, Histones/*metabolism, Insulin Receptor Substrate Proteins/metabolism, Insulin/*metabolism/pharmacology, Muscle Fibers, Skeletal/drug effects/*metabolism, Phosphatidylinositol 3-Kinases/metabolism, [SDV]Life Sciences [q-bio]

العلاقة: hal-01859362; https://hal.science/hal-01859362Test

الإتاحة: https://doi.org/10.1139/bcb-2013-0071Test
https://hal.science/hal-01859362Test