دورية أكاديمية
Impact of dietary fats on brain functions
| العنوان: | Impact of dietary fats on brain functions |
|---|---|
| المؤلفون: | Chianese, Rosanna, Coccurello, Roberto, Viggiano, Andrea, Scafuro, Marika, Fiore, Marco, Coppola, Giangennaro, Operto, Francesca Felicia, Fasano, Silvia, Layé, Sophie, Pierantoni, Riccardo, Meccariello, Rosaria |
| المساهمون: | University of Campania, Partenaires INRAE, Institute of Cell Biology and Neurobiology, National Research Council (CNR), Università degli Studi di Salerno (UNISA), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Università degli studi di Napoli Federico II |
| المصدر: | ISSN: 1570-159X ; Current Neuropharmacology ; https://hal.inrae.fr/hal-02623830Test ; Current Neuropharmacology, Bentham Science Publishers, 2018, 16 (7), pp.1059-1085. ⟨10.2174/1570159X15666171017102547⟩. |
| بيانات النشر: | HAL CCSD Bentham Science Publishers |
| سنة النشر: | 2018 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Fat, GnRH, PUFAs, endocannabinoids, epilepsy, ghrelin, hypothalamus, ketogenic diets, kisspeptin, nutrient sensing, reproduction, diet, leptin, metabolic sensors, microbiota, neuroprotection, [SDV]Life Sciences [q-bio], [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics |
| الوصف: | International audience ; Background : Adequate dietary intake and nutritional status have important effects on brain functions and on brain health. Energy intake and specific nutrients excess or deficiency from diet differently affect cognitive processes, emotions, behaviour, neuroendocrine functions and synaptic plasticity with possible protective or detrimental effects on neuronal physiology. Lipids, in particular, play structural and functional roles in neurons. Here the importance of dietary fats and the need to understand the brain mechanisms activated by peripheral and central metabolic sensors. Thus, the manipulation of lifestyle factors such as dietary interventions may represent a successful therapeutic approach to maintain and preserve brain health along lifespan. Methods : This review aims at summarizing the impact of dietary fats on brain functions. Results : Starting from fat consumption, nutrient sensing and food-related reward, the impact of gut-brain communications will be discussed in brain health and disease. A specific focus will be on the impact of fats on the molecular pathways within the hypothalamus involved in the control of reproduction via the expression and the release of Gonadotropin-Releasing Hormone. Lastly, the effects of specific lipid classes such as polyunsaturated fatty acids and of the "fattest" of all diets, commonly known as "ketogenic diets", on brain functions will also be discussed. Conclusion : Despite the knowledge of the molecular mechanisms is still a work in progress, the clinical relevance of the manipulation of dietary fats is well acknowledged and such manipulations are in fact currently in use for the treatment of brain diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29046155; hal-02623830; https://hal.inrae.fr/hal-02623830Test; PRODINRA: 438900; PUBMED: 29046155; WOS: 000438778700014 |
| DOI: | 10.2174/1570159X15666171017102547 |
| الإتاحة: | https://doi.org/10.2174/1570159X15666171017102547Test https://hal.inrae.fr/hal-02623830Test |
| رقم الانضمام: | edsbas.F67BA578 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1570159X15666171017102547 |
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