KCNQ2 Is a Nodal K+ Channel
| العنوان: | KCNQ2 Is a Nodal K+ Channel |
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| المؤلفون: | Kleopas A. Kleopa, Jérôme Devaux, Steven S. Scherer, Edward C. Cooper |
| المساهمون: | Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut des Neurosciences de Montpellier (INM), Devaux, jérôme |
| المصدر: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2004, 24 (5), pp.1236-1244. ⟨10.1523/JNEUROSCI.4512-03.2004⟩ |
| بيانات النشر: | HAL CCSD, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Potassium Channels, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Linopirdine, chemistry.chemical_compound, Mice, 0302 clinical medicine, M current, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Ankyrin, Benign familial neonatal seizures, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, 0303 health sciences, Chemistry, General Neuroscience, Retigabine, Brain, Immunohistochemistry, Sciatic Nerve, [SDV] Life Sciences [q-bio], Spinal Cord, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Potassium Channels, Voltage-Gated, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.drug, Cellular/Molecular, Ankyrins, Immunoblotting, KCNQ3 Potassium Channel, 03 medical and health sciences, Ranvier's Nodes, medicine, Repolarization, Animals, Humans, KCNQ2 Potassium Channel, Myokymia, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Rats, Wistar, 030304 developmental biology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Optic Nerve, medicine.disease, Axon initial segment, Precipitin Tests, Rats, nervous system, Amino Acid Substitution, Mutation, Neuroscience, 030217 neurology & neurosurgery, HeLa Cells |
| الوصف: | Mutations in the gene encoding the K+channel KCNQ2 cause neonatal epilepsy and myokymia, indicating that KCNQ2 regulates the excitability of CNS neurons and motor axons, respectively. We show here that KCNQ2 channels are functional components of axon initial segments and nodes of Ranvier, colocalizing with ankyrin-G and voltage-dependent Na+channels throughout the CNS and PNS. Retigabine, which opens KCNQ channels, diminishes axonal excitability. Linopirdine, which blocks KCNQ channels, prolongs the repolarization of the action potential in neonatal nerves. The clustering of KCNQ2 at nodes and initial segments lags that of ankyrin-G during development, and both ankyrin-G and KCNQ2 can be coimmunoprecipitated in the brain. KCNQ3 is also a component of some initial segments and nodes in the brain. The diminished activity of mutant KCNQ2 channels accounts for neonatal epilepsy and myokymia; the cellular locus of these effects may be axonal initial segments and nodes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0270-6474 1529-2401 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6682d1ac2222e899a27af318afa65e8Test https://hal.archives-ouvertes.fr/hal-02999281Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a6682d1ac2222e899a27af318afa65e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02706474 15292401 |
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