دورية أكاديمية
Endemic versus epidemic viral spreads display distinct patterns of intraindividual HTLV-2b replication.
| العنوان: | Endemic versus epidemic viral spreads display distinct patterns of intraindividual HTLV-2b replication. |
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| المؤلفون: | Gabet, As, Moules, V., Sibon, D., Nass, Cc, Mortreux, F., Mauclere, P., Gessain, A., Murphy, El, Wattel, E. |
| المساهمون: | Virologie et pathogenèse virale (VPV), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), American Red Cross Blood Services, Chesapeake Region, Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Department of Laboratory Medicine San Francisco, University of California San Francisco (UC San Francisco), University of California (UC)-University of California (UC), This work was supported by la Ligue Nationale Contre le Cancer (e´quipe labellise´e, 2003). ASG was supported by a grant from the Centre Le´on Be´rard and VM was supported by a grant from the Comite´ De´partemental de la Loire de la Ligue Nationale Contre le Cancer. The blood donor samples were obtained from the HTLV outcomes study (HOST) funded by grant RO1-HL-62235 from the National Heart, Lung and Blood Institute. |
| المصدر: | ISSN: 0042-6822. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2005 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Adult, Blood Donors, Carrier State/virology, Cell Proliferation, Child, DNA Fingerprinting, DNA, Viral/genetics, Endemic Diseases, Epidemiology, Molecular, Female, HTLV-II Infections/*epidemiology/*virology, Human T-lymphotropic virus 2/*physiology, Humans, Male, Middle Aged, Polymerase Chain Reaction, Proviruses/isolation & purification, Viral Load, Virus Replication, OCIS 000.1430, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | As the replication pattern of leukemogenic PTLVs possesses a strong pathogenic impact, we investigated HTLV-2 replication in vivo in asymptomatic carriers belonging into 2 distinct populations infected by the same HTLV-2b subtype. They include epidemically infected American blood donors, in whom HTLV-2b has been present for only 30 years, and endemically infected Bakola Pygmies from Cameroon, characterized by a long viral endemicity (at least few generations). In blood donors, both the circulating proviral loads and the degree of infected cell proliferation were largely lower than those characterizing asymptomatic carriers infected with leukemogenic PTLVs (HTLV-1, STLV-1). This might contribute to explain the lack of known link between HTLV-2b infection and the development of malignancies in this population. In contrast, endemically infected individuals displayed high proviral loads resulting from the extensive proliferation of infected cells. The route and/or the duration of infection, viral genetic drift, host immune response, genetic background, co-infections or a combination thereof might have contributed to these differences between endemically and epidemically infected subjects. As the clonality pattern observed in endemically infected individuals is very reminiscent of that of leukemogenic PTLVs at the pre-leukemic stage, our results highlight the possible oncogenic effect of HTLV-2b infection in such population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/16256162; hal-00124561; https://hal.science/hal-00124561Test; PUBMED: 16256162 |
| DOI: | 10.1016/j.virol.2005.08.026 |
| الإتاحة: | https://doi.org/10.1016/j.virol.2005.08.026Test https://hal.science/hal-00124561Test |
| رقم الانضمام: | edsbas.5F2771A5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.virol.2005.08.026 |
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