Assessing diabetic foot osteomyelitis remission with white blood cell SPECT/CT imaging
| العنوان: | Assessing diabetic foot osteomyelitis remission with white blood cell SPECT/CT imaging |
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| المؤلفون: | I. Morelec, J. Vouillarmet, C. Thivolet |
| المساهمون: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Diabetic Medicine Diabetic Medicine, Wiley, 2014, 31 (9), pp.1093-9. ⟨10.1111/dme.12445⟩ |
| بيانات النشر: | HAL CCSD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Biomarkers/analysis, Endocrinology, Leukocytes/immunology/*metabolism, Leukocytes, Osteomyelitis/drug therapy/etiology/immunology/*radionuclide imaging, Amputation, Diabetic Foot/complications/drug therapy/immunology/*radionuclide imaging, medicine.diagnostic_test, Remission Induction, Osteomyelitis, Middle Aged, Diabetic Foot, 3. Good health, Anti-Bacterial Agents, X-Ray Computed, medicine.anatomical_structure, Treatment Outcome, Predictive value of tests, Female, Radiology, medicine.medical_specialty, Tomography, Gallium Radioisotopes, Amputation, Surgical, Predictive Value of Tests, White blood cell, Internal Medicine, medicine, Humans, Risk factor, Aged, Tomography, Emission-Computed, Single-Photon, business.industry, medicine.disease, Diabetic foot, Anti-Bacterial Agents/*therapeutic use, Discontinuation, Bone scintigraphy, Emission-Computed, Radiopharmaceuticals, business, Tomography, X-Ray Computed, Biomarkers, Single-Photon |
| الوصف: | Aims Diabetic foot osteomyelitis is an important risk factor of lower limb amputation. Antibiotic therapy is often effective in preventing surgery. However, the duration of antibiotic therapy is difficult to define in the absence of a marker to diagnose osteomyelitis remission at the end of the treatment. In this study, we assessed the diagnostic performance of white blood cell SPECT/CT imaging for evaluating osteomyelitis remission. Patients and methods Twenty-nine out of 42 episodes of diabetic foot osteomyelitis seen between December 2009 and April 2012 had radiographs, a three-phase bone scintigraphy and a white blood cell SPECT/CT at the end of antibiotic therapy. They were treated with antibiotics alone and considered in clinical remission. White blood cell SPECT/CT results were considered positive when abnormal uptake in the osteomyelitis location was identified. Osteomyelitis remission was defined by the absence of an osteomyelitis relapse after 12 months’ follow-up. Results A negative white blood cell SPECT/CT was seen for 22 episodes of osteomyelitis. All of them were in remission. A positive white blood cell SPECT/CT was observed for seven episodes. A relapse occurred in five episodes (71.5%) after a median duration of 4 months (2–7 months). Sensitivity, specificity, positive predictive value and predictive negative value in predicting osteomyelitis relapse after the discontinuation of antibiotic treatment were, respectively, for radiographs 80%, 33%, 20% and 89%; for three-phase bone scintigraphy 100%, 12.5%, 15.5% and 100%; and for the white blood cell SPECT/CT 100%, 91.5%, 71.5% and 100%. Conclusion Negative uptake on white blood cell SPECT/CT is a good marker for diagnosis of diabetic foot osteomyelitis remission and might be very useful in guiding antibiotic therapy. |
| اللغة: | English |
| تدمد: | 0742-3071 1464-5491 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76dd2280415804739ec18e7fbafde95Test https://hal.archives-ouvertes.fr/hal-01859001Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c76dd2280415804739ec18e7fbafde95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07423071 14645491 |
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