Utility of 18F-FDG PET with a Semi-Quantitative Index in the Detection of Sarcomatous Transformation in Patients with Neurofibromatosis Type 1
| العنوان: | Utility of 18F-FDG PET with a Semi-Quantitative Index in the Detection of Sarcomatous Transformation in Patients with Neurofibromatosis Type 1 |
|---|---|
| المؤلفون: | Pierre Wolkenstein, Denis Mariano Goulart, Bernard Guillot, Francesco Giammarile, Patrick Combemale, Jean-Yves Blay, Stéphane Pinson, Thomas Mognetti, Laurence Valeyrie-Allanore |
| المساهمون: | Passerieux, Emilie, Centre Léon Bérard [Lyon], Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de génétique humaine [CHU Herriot], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | PLoS ONE PLoS ONE, 2014, 9 (2), pp.e85954. ⟨10.1371/journal.pone.0085954⟩ PLoS ONE, Vol 9, Iss 2, p e85954 (2014) PLoS ONE, Public Library of Science, 2014, 9 (2), pp.e85954. ⟨10.1371/journal.pone.0085954⟩ |
| بيانات النشر: | HAL CCSD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pathology, Epidemiology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, lcsh:Medicine, Likelihood ratios in diagnostic testing, Clinical Epidemiology, Child, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, Liver Neoplasms, Sarcoma, Middle Aged, 3. Good health, Cell Transformation, Neoplastic, Oncology, Liver, Positron emission tomography, Child, Preschool, Medicine, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Radiology, Cancer Epidemiology, Cancer Screening, Research Article, Adult, medicine.medical_specialty, Clinical Pathology, Neurofibromatosis 1, Adolescent, Clinical Research Design, [SDV.CAN]Life Sciences [q-bio]/Cancer, Malignancy, Text mining, [SDV.CAN] Life Sciences [q-bio]/Cancer, Diagnostic Medicine, Fluorodeoxyglucose F18, Cancer Detection and Diagnosis, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurofibromatosis, Retrospective Studies, Aged, Demography, business.industry, lcsh:R, Retrospective cohort study, Magnetic resonance imaging, medicine.disease, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Positron-Emission Tomography, lcsh:Q, business |
| الوصف: | International audience; Background: Malignant peripheral nerve sheath tumors (MPNSTs) are a serious complications of neurofibromatosis type 1 associated with poor prognosis and deeper lesions can be difficult to diagnose. 18-FDG PET improves the detection of malignancies. However, the criteria for malignancy, notably the SUVmax threshold, are not standardized. Therefore, the aim of the study was to evaluate a semi-quantitative index for the reproducible detection of MPNST with FDG PET.Methods: It is a multicenter retrospective study conducted between 2000 to 2012. All patients with NF1 referred for suspected MPNST underwent PET. Since SUVmax was not available until 2004 in our centers, we had to settle for the semi-quantitative method used at that time, the uptake ratio between the tumor and the normal liver (T/L ratio) with 1.5 as the cut-off for malignancy. When dedicated PET with SUVmax became available, the semi-quantitative analysis of PET images remained, along with SUVmax.Results: 113 patients with 145 tumors were included. PET assessment revealed 65 suspected lesions with T/L >1.5 and among these, 40 were MPNSTs. 80 tumors were classified as non-suspicious, and 79 were benign. The 1.5 T/L cut-off had a negative predictive value (NPV) of 98,8% and a positive predictive value of 61,5%. The positive likelihood ratio (LR) was 4,059, the negative LR was 0,032 with 97% sensitivity and 76% specificity.Conclusions: This study, which is among the largest published, confirms the utility of PET for detecting NF1-associated MPNSTs. A semi-quantitative index, the T/L ratio with a cut-off of 1.5, allowed sensitive and specific differentiation of malignant from benign tumors better than SUVmax. When T/L was 1.5, there was a strong suspicion of malignancy. This semi-quantitative analytical method is as simple as SUVmax, but is more sensitive, more reproducible and non-user-dependent |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a49a2e42327fd93bcd4af0b30251c6Test https://hal.umontpellier.fr/hal-02547621/documentTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8a49a2e42327fd93bcd4af0b30251c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|