المؤلفون: Ravi Reddy, Edward L. Murphy, Jabulisile Jaza, Olivier Cassar, Antoine Gessain, Charlotte Ingram, Marion Vermeulen, Charl Coleman, Colwyn Poole, Genevieve Jacobs, Wendy Sykes, Brian Custer, Zhanna Kaidarova, Carol Hlela

المساهمون: South African National Blood Service (SANBS), Vitalant Research Institute [San Francisco], University of California [San Francisco] (UCSF), University of California, Red Cross Children's Hospital [Cape Town, South Africa], Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), We would like to thank Vitalant Research Institute for partial funding and Abbott Diagnostics for providing a portion of the HTLV test kits. A special thanks to all the Donation Testing staff at SANBS for performing the testing in addition to their normal work. We would also like to thank Dr. Diana Hardie of the South African National Health Laboratory Service for performing the HTLV proviral DNA testing for confirmation of the Inno‐LIA results., University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

المصدر: Vox Sanguinis
Vox Sanguinis, Wiley, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩
Vox sanguinis, vol 114, iss 5
Vox Sang
Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; et al.(2019). The prevalence of human T-lymphotropic virus type 1 & 2 (HTLV-1/2) in South African blood donors.. Vox sanguinis. doi: 10.1111/vox.12778. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7582w44xTest
Vox Sanguinis, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩

مصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], Medical Physiology, Blood Donors, 030204 cardiovascular system & hematology, Human T-lymphotropic virus, Serology, Blood donations, South Africa, 0302 clinical medicine, MESH: South Africa, Seroepidemiologic Studies, Epidemiology, Prevalence, Mass Screening, donors, education.field_of_study, Human T-lymphotropic virus 1, MESH: Middle Aged, biology, Human T-lymphotropic virus 2, Blood Screening, Hematology, General Medicine, Middle Aged, 3. Good health, MESH: Young Adult, Female, MESH: HTLV-II Infections, Adult, medicine.medical_specialty, Adolescent, Population, Clinical Sciences, serological testing, Article, 03 medical and health sciences, Young Adult, MESH: HTLV-I Infections, medicine, Seroprevalence, Humans, MESH: Mass Screening, education, MESH: Prevalence, MESH: Adolescent, MESH: Seroepidemiologic Studies, MESH: Human T-lymphotropic virus 1, MESH: Humans, MESH: Human T-lymphotropic virus 2, business.industry, MESH: Blood Donors, MESH: Adult, Odds ratio, biology.organism_classification, HTLV-I Infections, MESH: Male, Cardiovascular System & Hematology, HTLV-II Infections, business, MESH: Female, 030215 immunology, Demography, transfusion - transmissible infections

الوصف: Author(s): Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; Kaidarova, Zhanna; Hlela, Carol; Gessain, Antoine; Cassar, Olivier; Poole, Colwyn; Ingram, Charlotte; Murphy, Edward L; Reddy, Ravi | Abstract: Background and objectivesDonated blood is not currently screened for human T-cell lymphotropic virus (HTLV) in South Africa. Several small studies have detected HTLV-1 in South Africa, but prevalence by geographic region or population group is unavailable.Materials and methodsWe performed a large seroprevalence study of South African blood donors during 3 months in 2013. All geographic regions except the Western Cape were included, and Black and Coloured (local term for mixed race) donors were oversampled. Identity-unlinked plasma samples were screened with the Abbott Prism HTLV-1/2 assay, and repeatedly reactive samples were tested by the Inno-LIA HTLV-1/2 Score confirmatory assay. Odds ratios were calculated with multivariable logistic regression.ResultsOf 46 752 donors tested, 133 (0·28%) were initially reactive, 111 (0·24%) repeatedly reactive and 57 (0·12%) confirmed positive for HTLV-1; none were HTLV-2 positive. Prevalence was 0·062% weighted to annual blood donations but highly concentrated in the Black population group (OR = 20·24 CI: 2·77-147·88); higher in females than males (OR = 1·81 CI: 1·06-3·08); and in donors aged g50 years compared to ages 16-19 (OR = 6·4 CI: 2·95-13·86). After controlling for age, sex and population group, there was no difference in prevalence between new and repeat blood donors or among geographic regions within South Africa.ConclusionsWe conclude that HTLV-1 infection is widespread among the Black population of South Africa and its epidemiology is similar to other endemic areas. Because South Africa is increasing its recruitment of Black blood donors, the implications for blood screening require further consideration.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c581e1ce940ab3f5ecf6cea7c07fe4fTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-03208040/documentTest

المؤلفون: Kaustav P. Shah, Javid Moslehi, Douglas B. Johnson, Haocan Song, Fei Ye, Justin M. Balko, Joe-Elie Salem

المساهمون: Vanderbilt University School of Medicine [Nashville], Service de pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gestionnaire, Hal Sorbonne Université, Service de Pharmacologie médicale [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

المصدر: Cancer Immunology Research
Cancer Immunology Research, American Association for Cancer Research, 2020, 8 (7), pp.851-855. ⟨10.1158/2326-6066.CIR-19-0986⟩
Cancer Immunology Research, 2020, 8 (7), pp.851-855. ⟨10.1158/2326-6066.CIR-19-0986⟩
Cancer Immunol Res

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Myocarditis, Adolescent, [SDV]Life Sciences [q-bio], Programmed Cell Death 1 Receptor, Immunology, Ipilimumab, Article, Young Adult, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Risk Factors, Internal medicine, Pharmacovigilance, medicine, Humans, Immunologic Factors, CTLA-4 Antigen, Young adult, Adverse effect, Melanoma, Aged, Pneumonitis, Aged, 80 and over, Hepatitis, business.industry, Age Factors, Length of Stay, Middle Aged, medicine.disease, 3. Good health, Hospitalization, [SDV] Life Sciences [q-bio], 030104 developmental biology, 030220 oncology & carcinogenesis, Female, Immunotherapy, Nivolumab, business, medicine.drug

الوصف: Immune checkpoint inhibitors (ICI) are now routinely used in multiple cancers but may induce autoimmune-like side effects known as immune-related adverse events (irAE). Although classical autoimmune diseases have well-known risk factors, including age, gender, and seasonality, the clinical factors that lead to irAEs are not well-defined. To explore these questions, we assessed 455 patients with advanced melanoma treated with ICI at our center and a large pharmacovigilance database (VigiBase). We found that younger age was associated with a similar rate of any irAEs but more frequent severe irAEs and more hospitalizations (OR, 0.97 per year). Paradoxically, however, older patients had more deaths and increased length of stay (LOS) when hospitalized. This was partially due to a distinct toxicity profile: Colitis and hepatitis were more common in younger patients, whereas myocarditis and pneumonitis had an older age distribution both in our center and in VigiBase. This pattern was particularly apparent with combination checkpoint blockade with ipilimumab and nivolumab. We did not find a link between gender or seasonality on development of irAEs in univariate or multivariate analyses, although winter hospitalizations were associated with marginally increased LOS. This study identifies age-specific associations of irAEs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df8051df7e975288586a2c82767394fTest
https://hal.sorbonne-universite.fr/hal-02948375Test

المؤلفون: Dalila Rezzoug, Cécile Vuillermoz, Stéphanie Vandentorren, Maria Melchior, M Roze, Thierry Baubet

المساهمون: Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Santé publique France - French National Public Health Agency [Saint-Maurice, France]

المصدر: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, MDPI, 2020, 17 (13), pp.4908. ⟨10.3390/ijerph17134908⟩
International Journal of Environmental Research and Public Health, Vol 17, Iss 4908, p 4908 (2020)
Volume 17
Issue 13

مصطلحات موضوعية: Male, Multivariate analysis, Health, Toxicology and Mutagenesis, lcsh:Medicine, Stress Disorders, Post-Traumatic, 0302 clinical medicine, 5. Gender equality, 030212 general & internal medicine, Child, Depression (differential diagnoses), health care economics and organizations, Qualitative Research, 1. No poverty, Traumatic stress, PTSD, humanities, 3. Good health, Ill-Housed Persons, symbols, behavior and behavior mechanisms, Female, homeless migrants, women, Psychology, mental health, Adult, medicine.medical_specialty, Paris, education, Mothers, Article, Interviews as Topic, 03 medical and health sciences, symbols.namesake, mental disorders, medicine, Humans, Poisson regression, Psychiatry, Mini-international neuropsychiatric interview, lcsh:R, Public Health, Environmental and Occupational Health, social sciences, Mental health, Country of origin, 030227 psychiatry, Sexual abuse, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Housing, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: Migrant women are disproportionately more likely to experience traumatic events in their country of origin, during migration and after arriving in the host country. Homeless women are more likely to be exposed to multiple victimizations in childhood (emotional or physical maltreatment) and in adulthood (sexual abuse, street victimization). This study&rsquo
s objective was to describe the factors associated with the likelihood of post-traumatic stress disorder (PTSD) among homeless migrant mothers in the Paris region. Face-to-face interviews were conducted by bilingual psychologists and interviewers in a representative sample of homeless families in the Paris region. PTSD was ascertained using the Mini International Neuropsychiatric Interview (MINI) (n = 691 mothers). We studied PTSD in mothers using weighted Poisson regression. Homeless migrant mothers had high levels of PTSD (18.9%) in the 12 months preceding the study. In multivariate analysis, PTSD was associated with departure from the country of origin because of violence (PR = 1.45 95% CI 1.03
2.04), depression in the preceding 12 months (PR = 1.82 95% CI 1.20
2.76), and residential instability (PR = 1.93 95% CI 1.27
2.93). Homeless migrant mothers have high levels of traumatic events and PTSD. Improvements in screening for depression and PTSD and access to appropriate medical care are essential for this vulnerable group.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ece796a6f6b3f4639b6e6ec2fbc0c7dTest
https://hal.sorbonne-universite.fr/hal-02934854/file/ijerph-17-04908-v2.pdfTest

المؤلفون: Justin Lee, Anne Farret, Ankush Chakrabarty, Marie‐José Pelletier, Eyal Dassau, Howard Zisser, Francis J. Doyle, Jerome Place, Eric Renard, Lauren M. Huyett

المساهمون: Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

المصدر: Diabetes, Obesity and Metabolism
Diabetes, Obesity and Metabolism, Wiley, 2017, 19 (12), pp.1698--1705. ⟨10.1111/dom.12999⟩

مصطلحات موضوعية: Blood Glucose, Male, model predictive control, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Pilot Projects, 030204 cardiovascular system & hematology, Infusions, Subcutaneous, 0302 clinical medicine, Endocrinology, Insulin, Regular, Human, Medicine, Infusions, Parenteral, Insulin Lispro, artificial pancreas, Middle Aged, insulin pump, DiaPort, Female, France, Algorithms, medicine.drug, Insulin pump, Adult, Pancreas, Artificial, medicine.medical_specialty, hypoglycaemia intraperitoneal, 030209 endocrinology & metabolism, Hypoglycemia, Artificial pancreas, Proof of Concept Study, Article, 03 medical and health sciences, Insulin Infusion Systems, Internal medicine, Internal Medicine, Insulin lispro, Humans, Hypoglycemic Agents, Glycated Hemoglobin, Type 1 diabetes, closed-loop, business.industry, CGM, Insulin, CSII, Carbohydrate, medicine.disease, Diabetes Mellitus, Type 1, Hyperglycemia, Regular insulin, business, hyperglycaemia

الوصف: International audience; To compare intraperitoneal (IP) to subcutaneous (SC) insulin delivery in an artificial pancreas (AP). RESEARCH DESIGN AND METHODS: Ten adults with type 1 diabetes participated in a non-randomized, non-blinded sequential AP study using the same SC glucose sensing and Zone Model Predictive Control (ZMPC) algorithm adjusted for insulin clearance. On first admission, subjects underwent closed-loop control with SC delivery of a fast-acting insulin analogue for 24 hours. Following implantation of a DiaPort IP insulin delivery system, the identical 24-hour trial was performed with IP regular insulin delivery. The clinical protocol included 3 unannounced meals with 70, 40 and 70 g carbohydrate, respectively. Primary endpoint was time spent with blood glucose (BG) in the range of 80 to 140 mg/dL (4.4-7.7 mmol/L). RESULTS: Percent of time spent within the 80 to 140 mg/dL range was significantly higher for IP delivery than for SC delivery: 39.8 \textpm 7.6 vs 25.6 \textpm 13.1 ( P = .03). Mean BG (mg/dL) and percent of time spent within the broader 70 to 180 mg/dL range were also significantly better for IP insulin: 151.0 \textpm 11.0 vs 190.0 \textpm 31.0 ( P = .004) and 65.7 \textpm 9.2 vs 43.9 \textpm 14.7 ( P = .001), respectively. Superiority of glucose control with IP insulin came from the reduced time spent in hyperglycaemia (\textgreater180 mg/dL: 32.4 \textpm 8.9 vs 53.5 \textpm 17.4, P = .014; \textgreater250 mg/dL: 5.9 \textpm 5.6 vs 23.0 \textpm 11.3, P = .0004). Higher daily doses of insulin (IU) were delivered with the IP route (43.7 \textpm 0.1 vs 32.3 \textpm 0.1, P \textless .001) with no increased percent time spent \textless70 mg/dL (IP: 2.5 \textpm 2.9 vs SC: 4.1 \textpm 5.3, P = .42). CONCLUSIONS: Glycaemic regulation with fully-automated AP delivering IP insulin was superior to that with SC insulin delivery. This pilot study provides proof-of-concept for an AP system combining a ZMPC algorithm with IP insulin delivery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286684e8ff388f713247b41611bb2a47Test
https://hal.archives-ouvertes.fr/hal-01761874Test

المؤلفون: Sophie Edouard, P. Brouqui, P. Gautret, V. Pommier de Santi, Sékéné Badiaga, Van Thuan Hoang, Hervé Tissot-Dupont, Didier Raoult, Tran Duc Anh Ly

المساهمون: Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Guyane (UG), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)

المصدر: Clinical Microbiology and Infection
Clinical Microbiology and Infection, 2019, 25 (2), pp.249.e1-249.e6. ⟨10.1016/j.cmi.2018.04.032⟩
Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2019, 25 (2), pp.249.e1-249.e6. ⟨10.1016/j.cmi.2018.04.032⟩

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, Quantitative polymerase chain reaction, Risk Factors, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Epidemiology, Odds Ratio, medicine, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030212 general & internal medicine, Respiratory Tract Infections, Nose, ComputingMilieux_MISCELLANEOUS, Quantitative reverse transcription–polymerase chain reaction, Respiratory symptoms and signs, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Respiratory pathogen carriage, Respiratory tract infections, business.industry, Transmission (medicine), 1. No poverty, General Medicine, Odds ratio, Middle Aged, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Cross-Sectional Studies, Infectious Diseases, medicine.anatomical_structure, Carriage, Virus Diseases, Ill-Housed Persons, Viruses, Homeless, France, Rhinovirus, business, Respiratory tract, Demography

الوصف: Objectives To assess risk factors for respiratory tract infection symptoms and signs in sheltered homeless people in Marseille during the winter season, including pathogen carriage. Methods Data on 479 male participants within two shelters who completed questionnaires and a total of 950 nasal and pharyngeal samples were collected during the winters of 2015–2017. Respiratory pathogen carriage including seven viruses and four bacteria was assessed by quantitative PCR. Results The homeless population was characterized by a majority of individuals of North African origin (300/479, 62.6%) with a relatively high prevalence of chronic homelessness (175/465, 37.6%). We found a high prevalence of respiratory symptoms and signs (168/476, 35.3%), a very high prevalence of bacterial carriage (313/477, 65.6%), especially Haemophilus influenzae (280/477, 58.7%), and a lower prevalence of virus carriage (51/473, 10.8%) with human rhinovirus being the most frequent (25/473, 5.3%). Differences were observed between the microbial communities of the nose and throat. Duration of homelessness (odds ratio (OR) 1.77, p 0.017), chronic respiratory diseases (OR 5.27, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1137d161cbed2d9730390d9e6d08594Test
https://hal-amu.archives-ouvertes.fr/hal-02006002Test

المؤلفون: Rabab Debs, Jean-Yves Hogrel, Gaëlle Bruneteau, Tanya Stojkovic, Maria del Mar Amador, Julien Cohen-Adad, Lucette Lacomblez, David Devos, Nadine Le Forestier, Peter Bede, Timothée Lenglet, Menghan Li, Sophie Blancho, Pierre-François Pradat, Pascal Laforêt, Anthony Behin, François Salachas, Habib Benali, Martin Catala, Véronique Marchand-Pauvert, Mohamed-Mounir El Mendili, Stéphane Lehéricy, Vincent Meininger, Giorgia Querin

المساهمون: Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centres de référence pour la sclérose latérale amyotrophique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département de Recherche en Ethique, Université Paris-Sud - Paris 11 (UP11), École Polytechnique de Montréal (EPM), Université de Montréal (UdeM), Unité de Neuroimagerie Fonctionnelle [Montréal] (UNF-CRIUGM), Université de Montréal (UdeM)-Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Neuro-Imagerie de Recherche (CENIR), Hôpital Raymond Poincaré [AP-HP], Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Concordia University [Montreal], Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Trinity College Dublin, University of Ulster, CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U1171, Lille Neurosciences & Cognition (LilNCog) - U 1172, Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Gestionnaire, Hal Sorbonne Université, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2019, 21, pp.101618. ⟨10.1016/j.nicl.2018.101618⟩
Neuroimage-Clinical, 2019, 21, pp.101618. ⟨10.1016/j.nicl.2018.101618⟩
NeuroImage : Clinical
NeuroImage: Clinical, Vol 21, Iss, Pp-(2019)

مصطلحات موضوعية: Male, Pathology, UMN, Upper motor neuron, [SDV]Life Sciences [q-bio], LL, Lower limb, RD, Radial diffusivity, Spinal Muscular Atrophies of Childhood, lcsh:RC346-429, ALS, Amyotrophic lateral sclerosis, 0302 clinical medicine, Grey matter and white matter degeneration, Spinal cord MRI, Multimodal MRI, SMA, Spinal muscular atrophy, Medicine, FA, Fractional anisotropy, Gray Matter, SMA, Spinal muscular atrophy, GM, Grey matter, UL, Upper limb, HC, Healthy control, 05 social sciences, Brain, Middle Aged, Magnetic Resonance Imaging, White Matter, FWE, Familywise error, TR, repetition time, [SDV] Life Sciences [q-bio], Diffusion Tensor Imaging, medicine.anatomical_structure, Spinal Cord, Neurology, FOV, Field-of-view, WM, White matter, lcsh:R858-859.7, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], EPI, Echo-planar imaging, Motor cortex, Adult, CST, Corticospinal tract, medicine.medical_specialty, CSA, cross-sectional area, Grey matter, Adolescent, ROI, Region-of-interest, MNI, Montreal Neurological Institute, Cognitive Neuroscience, LMN, Lower motor neuron, SC, Spinal cord, lcsh:Computer applications to medicine. Medical informatics, Lower motor neuron, Article, 050105 experimental psychology, MND, Motor neuron disease, Muscular Atrophy, Spinal, White matter, Young Adult, 03 medical and health sciences, AD, Axial diffusivity, Neuroimaging, TE, Echo time, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], lcsh:Neurology. Diseases of the nervous system, Aged, [SDV.IB] Life Sciences [q-bio]/Bioengineering, MD, mean diffusivity, SMAFRS, SMA functional rating scale, business.industry, VBM, Voxel-based morphometry, SMN1, Survival-motor-neuron 1 gene, MRC, Medical Research Council, TFCE, Threshold-free cluster enhancement, medicine.disease, Spinal cord, white matter degeneration, FDR, False discovery rate, DTI, diffusion tensor imaging, Neurology (clinical), 6MWT, Six-minute walk test, business, TBSS, Tract-based spatial statistics, 030217 neurology & neurosurgery

الوصف: Spinal muscular atrophy (SMA) type III and IV are autosomal recessive, slowly progressive lower motor neuron syndromes. Nevertheless, wider cerebral involvement has been consistently reported in mouse models. The objective of this study is the characterisation of spinal and cerebral pathology in adult forms of SMA using multimodal quantitative imaging. Methods Twenty-five type III and IV adult SMA patients and 25 age-matched healthy controls were enrolled in a spinal cord and brain imaging study. Structural measures of grey and white matter involvement and diffusion parameters of white matter integrity were evaluated at each cervical spinal level. Whole-brain and region-of-interest analyses were also conducted in the brain to explore cortical thickness, grey matter density and tract-based white matter alterations. Results In the spinal cord, considerable grey matter atrophy was detected between C2-C6 vertebral levels. In the brain, increased grey matter density was detected in motor and extra-motor regions of SMA patients. No white matter pathology was identified neither at brain and spinal level. Conclusions Adult forms of SMA are associated with selective grey matter degeneration in the spinal cord with preserved white matter integrity. The observed increased grey matter density in the motor cortex may represent adaptive reorganisation.
Highlights • (SMA) type 3 and 4 is a lower motor neuron syndrome. Nevertheless, wider involvement of the nervous system might be possible. • 25 adults type 3 and 4 SMA patients were studied using brain and cervical spinal cord neuroimaging techniques. • Grey matter atrophy was observed in the spinal cord. No white matter degeneration was present at brain and spinal level. • Increased grey matter density was detected in cerebral motor regions and explained as compensatory mechanism.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d677f059efc03030b5919d29d82dbeTest
https://hal.sorbonne-universite.fr/hal-02090969Test

المؤلفون: Florent Fuchs, Marie Houllier, Hervé Fernandez, Anne Guyot, Marie-Victoire Senat, Soizic Leparco

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Gynécologie Obstétrique [AP-HP Hôpital Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), This work was supported by MEDIX BIOCHEMICA and ALERE, who provided the cervical phIGFBP-1 test free of charge., Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Fuchs, Florent

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.10856. ⟨10.1038/s41598-017-11447-y⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Preterm labor, lcsh:Medicine, Cervix Uteri, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, Risk Factors, medicine, Odds Ratio, Humans, 030212 general & internal medicine, Young adult, Prospective cohort study, lcsh:Science, Cervical length, Gynecology, 030219 obstetrics & reproductive medicine, Multidisciplinary, business.industry, Obstetrics, lcsh:R, Infant, Newborn, Odds ratio, Intact membranes, medicine.disease, Prognosis, 3. Good health, Insulin-Like Growth Factor Binding Protein 1, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, C-Reactive Protein, Gestation, Premature Birth, Female, lcsh:Q, business, Biomarkers

الوصف: We aimed to assess the accuracy of cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test alone or in combination with cervical length (CL), to predict preterm birth (PTB) in symptomatic women. We performed a prospective cohort study from 2012 to 2015 including singleton pregnancies with symptoms of preterm labor, intact membranes and CL

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d154390b17b43b044b9e5c8f7d1a72Test
https://www.hal.inserm.fr/inserm-01611488Test

المؤلفون: Somnoma Jean-Baptiste Tougouma, Florence Fournet, Augustin Nawidimbasba Zeba, Marceline Téné Yaméogo, Daouda Kassie

المساهمون: Institut de Recherche en Sciences de la Santé (IRSS), CNRST, Université Polytechnique de Bobo Dioulasso, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Diversity, ecology, evolution & Adaptation of arthropod vectors (MIVEGEC-DEEVA), Evolution des Systèmes Vectoriels (ESV), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])

المصدر: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, MDPI, 2017, Urban Place and Health Equity, 14 (4), pp.378. ⟨10.3390/ijerph14040378⟩
International Journal of Environmental Research and Public Health; Volume 14; Issue 4; Pages: 378
International Journal of Environmental Research and Public Health, 2017, Urban Place and Health Equity, 14 (4), pp.378. ⟨10.3390/ijerph14040378⟩
International Journal of Environmental Research and Public Health, Vol 14, Iss 4, p 378 (2017)

مصطلحات موضوعية: Male, Bobo-Dioulasso, Cross-sectional study, chronic diseases, urbanization, health disparities, spatial sampling, medium-sized city, Health, Toxicology and Mutagenesis, lcsh:Medicine, Overweight, L73 - Maladies des animaux, Santé publique, 0302 clinical medicine, Environmental protection, Risk Factors, maladie cardiovasculaire, Facteur de risque, Medicine, 030212 general & internal medicine, 2. Zero hunger, education.field_of_study, Enquête, 1. No poverty, 000 - Autres thèmes, Middle Aged, Health equity, 3. Good health, B10 - Géographie, Hypertension, Female, Échantillonnage, medicine.symptom, Adult, medicine.medical_specialty, Zone urbaine, Population, Gestion du risque, Processus chronique, 030209 endocrinology & metabolism, Urbanisation, Article, 03 medical and health sciences, Maladie de l'homme, Ville, Urbanization, Environmental health, Burkina Faso, Population urbaine, Humans, education, Socioeconomic status, business.industry, Public health, lcsh:R, Public Health, Environmental and Occupational Health, Distribution spatiale, Trouble du métabolisme, Cross-Sectional Studies, Socioeconomic Factors, Hyperglycemia, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, U30 - Méthodes de recherche, business, Body mass index

الوصف: International audience; Background: Unplanned urbanization plays a key role in chronic disease growth. This population-based cross-sectional study assessed the occurrence of cardiometabolic risk factors in Bobo-Dioulasso and their association with urbanization conditions.Methods: Through spatial sampling, four Bobo-Dioulasso sub-spaces were selected for a population survey to measure the adult health status. Yéguéré, Dogona, Tounouma and Secteur 25 had very different urbanization conditions (position within the city; time of creation and healthcare structure access). The sample size was estimated at 1000 households (250 for each sub-space) in which one adult (35 to 59-year-old) was randomly selected. Finally, 860 adults were surveyed. Anthropometric, socioeconomic and clinical data were collected. Arterial blood pressure was measured and blood samples were collected to assess glycemia.Results: Weight, body mass index and waist circumference (mean values) and serum glycemia (83.4 mg/dL ± 4.62 mmol/L) were significantly higher in Tounouma, Dogona, and Secteur 25 than in Yéguéré; the poorest and most rural-like sub-space (p = 0.001). Overall, 43.2%, 40.5%, 5.3% and 60.9% of participants had overweight, hypertension, hyperglycemia and one or more cardiometabolic risk markers, respectively.Conclusions: Bobo-Dioulasso is unprepared to face this public health issue and urgent responses are needed to reduce the health risks associated with unplanned urbanization.

وصف الملف: application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c2815a8092d92b4218a0a333c8dd26Test
https://hal.umontpellier.fr/hal-02015226/documentTest

المؤلفون: Séverine Dubois, Pierre Abraham, Anne Humeau-Heurtier, P H Ducluzeau, E Parot-Schinkel, Lydie Gascoin, Guillaume Mahé, P Marche

المساهمون: school of arts, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), El Colegio de San Luis, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie Neurovasculaire et Mitochondriale Intégrée (BNMI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Angers (UA), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (44322), pp.article id. 44322. ⟨10.1038/srep44322⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.44322. ⟨10.1038/srep44322⟩
Scientific Reports, 2017, 7 (1), pp.44322. ⟨10.1038/srep44322⟩

مصطلحات موضوعية: Adult, Male, Nitroprusside, medicine.medical_specialty, Endothelium, Vasodilator Agents, [SDV]Life Sciences [q-bio], TRPV1, TRPV Cation Channels, Vasodilation, 030204 cardiovascular system & hematology, TRPV, Article, Microcirculation, Young Adult, 03 medical and health sciences, Transient receptor potential channel, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Nerve Fibers, Unmyelinated, Multidisciplinary, business.industry, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Acetylcholine, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Anesthesia, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Endothelium, Vascular, Sodium nitroprusside, business, 030217 neurology & neurosurgery, medicine.drug

الوصف: Microvascular dysfunction may have an early onset in type 1 diabetes (T1D) and can precede major complications. Our objectives were to assess the endothelial-dependent (acetylcholine, ACh; and post-occlusive hyperemia, PORH), non-endothelial-dependent (sodium nitroprusside, SNP) and neurovascular-dependent (local heating, LH and current induced vasodilation, CIV) microcirculatory vasodilation in T1D patients compared with matched control subjects using a laser speckle contrast imager. Seventeen T1D patients - matched with 17 subjects according to age, gender, Body-Mass-Index, and smoking status - underwent macro- and microvascular investigations. The LH early peak assessed the transient receptor potential vanilloid type 1 channels (TRPV1) mediated vasodilation, whereas the plateau assessed the Nitirc-Oxyde (NO) and endothelium-derived hyperpolarizing factor (EDHF) pathways. PORH explored sensory nerves and (EDHF), while CIV assessed sensory nerves (C-fibers) and prostaglandin-mediated vasodilation. Using neurological investigations, we observed that C-fiber and A-delta fiber functions in T1D patients were similar to control subjects. PORH, CIV, LH peak and plateau vasodilations were significantly decreased in T1D patients compared to controls, whereas there was no difference between the two groups for ACh and SNP vasodilations. Neurovascular microcirculatory vasodilations (C-fibers and TRPV 1-mediated vasodilations) are impaired in TD1 patients whereas no abnormalities were found using clinical neurological investigations. Clinicaltrials: No. NCT02538120.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd77a611a6d7896fac83c31681fa532Test
https://hal.archives-ouvertes.fr/hal-02159258Test

المؤلفون: Laura Gillard, Anne-Charlotte Jarry, Bogdan Stan-Iuga, Maude Le Gall, André Bado, Francisca Joly, Lara Ribeiro-Parenti, Camille Mayeur, Lore Billiauws, Françoise Cluzeaud, Jean-Baptiste Cavin, Jean-Noël Freund, Muriel Thomas, Johanne Le Beyec, Jean-Marc Lacorte

المساهمون: Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Gastroentérologie et d’Assistance nutritive [AP-HP Hôpital Beaujon], Université Paris Diderot - Paris 7 (UPD7)-AP-HP Hôpital Beaujon, Service de Chirurgie Générale et Digestive [Hôpital Bichat - Claude Bernard, Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris], MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), Université Paris-Sorbonne (UP4), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Service de Biochimie Endocrinienne et Oncologique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Joly, Francisca, Le Beyec, Johanne, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Biochimie Endocrinienne et Oncologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), LE GALL, Maude

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, Scientific Reports 6, Article number: 28345 (2016), [Epub ahead of print]. ⟨10.1038/srep28345⟩
Scientific Reports (6), 28345. (2016)
Scientific Reports, 2016, Scientific Reports 6, Article number: 28345 (2016), [Epub ahead of print]. ⟨10.1038/srep28345⟩

مصطلحات موضوعية: Male, 0301 basic medicine, Proglucagon, 0302 clinical medicine, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Agouti-Related Protein, Neuropeptide Y, Intestinal Mucosa, contrôle endocrinien, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, Anastomosis, Surgical, digestive, oral, and skin physiology, Middle Aged, Short bowel syndrome, Glucagon-like peptide-2, Glucagon-like peptide-1, Jejunum, ghrelin, Female, 030211 gastroenterology & hepatology, Ghrelin, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, Short Bowel Syndrome, medicine.medical_specialty, Colon, Hypothalamus, Neuropeptide, Hyperphagia, Biology, Real-Time Polymerase Chain Reaction, Article, maladie intestinale, 03 medical and health sciences, Orexigenic, Internal medicine, medicine, Animals, Humans, Peptide YY, RNA, Messenger, Rats, Wistar, neuropeptide, Aged, Feeding Behavior, medicine.disease, Rats, Disease Models, Animal, Ki-67 Antigen, 030104 developmental biology, Endocrinology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: Short bowel syndrome (SBS) patients developing hyperphagia have a better outcome. Gastrointestinal endocrine adaptations help to improve intestinal functions and food behaviour. We investigated neuroendocrine adaptations in SBS patients and rat models with jejuno-ileal (IR-JI) or jejuno-colonic (IR-JC) anastomosis with and without parenteral nutrition. Circulating levels of ghrelin, PYY, GLP-1, and GLP-2 were determined in SBS rat models and patients. Levels of mRNA for proglucagon, PYY and for hypothalamic neuropeptides were quantified by qRT-PCR in SBS rat models. Histology and immunostaining for Ki67, GLP-1 and PYY were performed in SBS rats. IR-JC rats, but not IR-JI, exhibited significantly higher crypt depths and number of Ki67-positive cells than sham. Fasting and/or postprandial plasma ghrelin and PYY concentrations were higher, or tend to be higher, in IR-JC rats and SBS-JC patients than in controls. Proglucagon and Pyy mRNA levels were significantly enhanced in IR-JC rats. Levels of mRNA coding hypothalamic orexigenic NPY and AgRP peptides were significantly higher in IR-JC than in sham rats. We demonstrate an increase of plasma ghrelin concentrations, major changes in hypothalamic neuropeptides levels and greater induction of PYY in SBS-JC rats and patients suggesting that jejuno-colonic continuity creates a peculiar environment promoting further gut-brain adaptations.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649af728e52b17efaf9bf2f5039f0743Test
https://www.hal.inserm.fr/inserm-01346345Test