Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis
| العنوان: | Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis |
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| المؤلفون: | Selma Rivas-Fuentes, Christophe Combadière, Rachel Nadif, Steven R. Kleeberger, Margaret Mintz, Anne E. Jedlicka, Mathieu P Rodero, Elise Lavergne, Francine Kauffmann |
| المساهمون: | Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie cellulaire et tissulaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et Biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Laboratory of Respiratory Biology, National Institutes of Health [Bethesda] (NIH), Action Thématique Concertée Environnement&Santé 2003 ATC-ASE04080LSA, Nadif, Rachel, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Cytokine Cytokine, Elsevier, 2006, 33 (3), pp.171-178. ⟨10.1016/J.CYTO.2006.01.001⟩ Cytokine, 2006, 33 (3), pp.171-8. ⟨10.1016/j.cyto.2006.01.001⟩ Cytokine, Elsevier, 2006, 33 (3), pp.171-8. ⟨10.1016/j.cyto.2006.01.001⟩ Cytokine, 2006, 33 (3), pp.171-178. ⟨10.1016/J.CYTO.2006.01.001⟩ |
| بيانات النشر: | HAL CCSD, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | CCR2, Chemokine, [SDV]Life Sciences [q-bio], MESH: Receptors, CCR5, Biochemistry, Gastroenterology, MESH: Genotype, Chemokine receptor, 0302 clinical medicine, Gene Frequency, CX3CR1, Prevalence, Immunology and Allergy, Receptor, Chemokine CCL5, Chemokine CCL2, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, MESH: Middle Aged, biology, Pneumoconiosis, MESH: Polymorphism, Single Nucleotide, Hematology, Middle Aged, MESH: Chemokines, 3. Good health, MESH: Chemokines, CC, Phenotype, medicine.anatomical_structure, Chemokines, CC, Receptors, Chemokine, MESH: Membrane Proteins, Chemokines, Adult, medicine.medical_specialty, Genotype, Receptors, CCR5, Receptors, CCR2, MESH: Pneumoconiosis, MESH: Receptors, Ch, Immunology, CX3C Chemokine Receptor 1, MESH: Phenotype, Polymorphism, Single Nucleotide, Article, CCL5, 03 medical and health sciences, Internal medicine, MESH: Polymorphism, Genetic, medicine, MESH: Gene Frequency, Humans, MESH: Coal Mining, Molecular Biology, MESH: Chemokine CCL2, MESH: Prevalence, 030304 developmental biology, Polymorphism, Genetic, Lung, MESH: Humans, Membrane Proteins, MESH: Adult, medicine.disease, Coal Mining, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | Chemokines and their receptors are key regulators of inflammation and may participate in the lung fibrotic process. Associations of polymorphisms in CCL5 (G-403A) and its receptor CCR5 (Delta32), CCL2 (A-2578G) and CCR2 (V64I), and CX3CR1 V249I and T280M with coal worker's pneumoconiosis (CWP) were investigated in 209 miners examined in 1990, 1994 and 1999. Coal dust exposure was assessed by job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-year change in CT score, and CWP prevalence in 1999. CCR5 Delta32 carriers had significantly higher CT score in 1990 and 1994 (2.15 vs. 1.28, p=0.01; 3.04 vs. 1.80, p=0.04). The CX3CR1 I249 allele was significantly associated with lower 1990 CT score and lower progression in 4-year change in CT score in CCR5 Delta32 carriers only (p for interaction=0.03 and 0.02). CX3CR1 V249I was associated with lower 1999 CWP prevalence (16.7%, 13.2%, 0.0% for VV, VI and II); the effect was most evident in miners with high dust exposure (31.6%, 21.7%, 0.0%). Our findings indicate that chemokine receptors CCR5 and CX3CR1 may be involved in the development of pneumoconiosis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1043-4666 1096-0023 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a2e47ee217438e915dba0e2ef4002bTest https://hal.archives-ouvertes.fr/hal-02998852Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....71a2e47ee217438e915dba0e2ef4002b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10434666 10960023 |
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