دورية أكاديمية
BMP 2 and BMP 4 genes expression in the development of the embryo heart in induced gestational diabetes of C57BL/6 mice
| العنوان: | BMP 2 and BMP 4 genes expression in the development of the embryo heart in induced gestational diabetes of C57BL/6 mice |
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| المؤلفون: | Fatemeh Ghasemzadeh, Masoud Golalipour, Kamran Haidari, Zahra Nazari, Mohamad Jafar Golalipour |
| المصدر: | مجله دانشگاه علوم پزشکی گرگان, Vol 20, Iss 3, Pp 19-23 (2018) |
| بيانات النشر: | Golestan University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Gestational diabetes mellitus, Heart development, BMP2 gene, BMP4 gene, Mouse, Medicine, Medicine (General), R5-920 |
| الوصف: | Background and Objective: Gestational diabetes mellitus (GDM) is usually a disease caused by inadequate insulin production in pregnant women. GDM induces abnormal fetal growth.This study was done to evaluate the BMP2 and BMP4 genes expression in the development of the embryos heart in induced gestational diabetes of C57BL/6 mice. Methods: In this experimental study, 8-week old adult C57BL/6 mice were randomly divided into diabetic and control groups. After mating of animals, the dams in diabetic group were received a single dose of 150 mg/kg/bw of streptozotocin on gestational day 1 of pregnancy, intrapereatonally. After 11.5 days of pregnancy, the embryos of both groups were extracted and heart tissue was extracted. RNA total tissue of the heart was extracted by trazole. After extracting RNA, expression of BMP2 and BMP4 genes in the heart of both groups was estimated by Real-time PCR. Results: There was no singnificant diference in expression of BMP2 and BMP4 genes in the heart of 11.5 days of embryos in gestational diabetes mellitus group and control group. Conclusion: Gestational diabetes mellitus had no effect on the expression of BMP2 and BMP4 genes in the development of the embryos heart. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 1562-4765 2008-4080 |
| العلاقة: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-1057&slc_lang=en&sid=1Test; https://doaj.org/toc/1562-4765Test; https://doaj.org/toc/2008-4080Test |
| الوصول الحر: | https://doaj.org/article/a777b33b0abe4115976997afdb608a8cTest |
| رقم الانضمام: | edsdoj.777b33b0abe4115976997afdb608a8c |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15624765 20084080 |
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