دورية أكاديمية
Endothelial dysfunction: A strategic target in the treatment of hypertension?
| العنوان: | Endothelial dysfunction: A strategic target in the treatment of hypertension? |
|---|---|
| المؤلفون: | Tang, EHC, Vanhoutte, PM |
| بيانات النشر: | //link.springer.de/link/service/journals/00424/index.htm Germany |
| سنة النشر: | 2010 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Prostaglandin, Free radical, Endothelium, Contraction, Hypertensive rats, Prostaglandin-Endoperoxide Synthases - metabolism, Hypertension - drug therapy - physiopathology, Vascular - physiopathology, Antihypertensive Agents - therapeutic use, Reactive Oxygen Species - metabolism |
| الوصف: | Endothelial dysfunction is a common feature of hypertension, and it results from the imbalanced release of endothelium-derived relaxing factors (EDRFs; in particular, nitric oxide) and endothelium-derived contracting factors (EDCFs; angiotensin II, endothelins, uridine adenosine tetraphosphate, and cyclooxygenase-derived EDCFs). Thus, drugs that increase EDRFs (using direct nitric oxide releasing compounds, tetrahydrobiopterin, or l-arginine supplementation) or decrease EDCF release or actions (using cyclooxygenase inhibitor or thromboxane A2/prostanoid receptor antagonists) would prevent the dysfunction. Many conventional antihypertensive drugs, including angiotensin-converting enzyme inhibitors, calcium channel blockers, and third-generation β-blockers, possess the ability to reverse endothelial dysfunction. Their use is attractive, as they can address arterial blood pressure and vascular tone simultaneously. The severity of endothelial dysfunction correlates with the development of coronary artery disease and predicts future cardiovascular events. Thus, endothelial dysfunction needs to be considered as a strategic target in the treatment of hypertension. © 2010 Springer-Verlag. ; postprint |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1432-2013 0031-6768 |
| العلاقة: | Pflugers Archiv European Journal of Physiology; http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952891127&selection=ref&src=s&origin=recordpageTest; Pflugers Archiv European Journal Of Physiology, 2010, v. 459 n. 6, p. 995-1004; 6803434; 1004; 192141; WOS:000277376200019; eid_2-s2.0-77952891127; 995; http://hdl.handle.net/10722/139591Test; 459 |
| DOI: | 10.1007/s00424-010-0786-4 |
| الإتاحة: | https://doi.org/10.1007/s00424-010-0786-4Test http://hdl.handle.net/10722/139591Test |
| حقوق: | The original publication is available at www.springerlink.com ; This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| رقم الانضمام: | edsbas.DF1862A0 |
| قاعدة البيانات: | BASE |
| تدمد: | 14322013 00316768 |
|---|---|
| DOI: | 10.1007/s00424-010-0786-4 |