دورية أكاديمية
The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma
| العنوان: | The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma |
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| المساهمون: | College of Medicine, Dept. of Pathology, Hyunsoo Cho, Se Hoon Kim, Soo-Jeong Kim, Jong Hee Chang, Woo Ick Yang, Chang-Ok Suh, June-Won Cheong, Yu Ri Kim, Jung Yeon Lee, Ji Eun Jang, Yundeok Kim, Yoo Hong Min, Jin Seok Kim, Kim, Se Hoon, Jang, Ji Eun, Cheong, June Won, Kim, Soo Jeong, Kim, Yu Ri, Kim, Yun Deok, Kim, Jin Seok, Min, Yoo Hong, Suh, Chang Ok, Yang, Woo Ick, Lee, Jung Yoen, Chang, Jong Hee, Cheong, June-Won |
| بيانات النشر: | Springer International Germany |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Aged, Antigens, CD/metabolism, Differentiation, Myelomonocytic/metabolism, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Central Nervous System Neoplasms/metabolism, Central Nervous System Neoplasms/pathology, Central Nervous System Neoplasms/therapy, Combined Modality Therapy, Female, Forkhead Transcription Factors/metabolism, Hematopoietic Stem Cell Transplantation/methods, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphoma/metabolism, Lymphoma/pathology, Lymphoma/therapy, Male, Methotrexate/administration & dosage, Middle Aged, Multivariate Analysis, Outcome Assessment (Health Care)/methods, Outcome Assessment (Health Care)/statistics & numerical data, Prognosis, Proportional Hazards Models, Retrospective Studies, Transplantation |
| الوصف: | The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively. High CD68 expression was associated with inferior overall survival (OS) and progression-free survival (PFS) in multivariate analysis (P = 0.023 and P = 0.021, respectively). In addition, we performed subgroup analysis based on upfront ASCT. High CD68 expression was also associated with inferior OS and PFS in multivariate analysis (P = 0.013 and P < 0.001, respectively) among patients who did not receive upfront ASCT (n = 60), but not in patients who received upfront ASCT. The expression of FoxP3 was not significantly associated with survival. Therefore, we identified a prognostic significance of high CD68 expression in PCNSL, which suggests a need for further clinical trials and biological studies on the role of PCNSL tumor microenvironment. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0939-5555 1432-0584 |
| العلاقة: | ANNALS OF HEMATOLOGY; J00161; OAK-2017-02340; https://ir.ymlib.yonsei.ac.kr/handle/22282913/153493Test; https://link.springer.com/article/10.1007%2Fs00277-017-3014-xTest; T201701748; ANNALS OF HEMATOLOGY, Vol.96(7) : 1163-1173, 2017 |
| DOI: | 10.1007/s00277-017-3014-x |
| الإتاحة: | https://doi.org/10.1007/s00277-017-3014-xTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/153493Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.6D024F99 |
| قاعدة البيانات: | BASE |
| تدمد: | 09395555 14320584 |
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| DOI: | 10.1007/s00277-017-3014-x |