دورية أكاديمية
Clinical, histological, and immunohistochemical features predicting 1p/19q loss of heterozygosity in oligodendroglial tumors
| العنوان: | Clinical, histological, and immunohistochemical features predicting 1p/19q loss of heterozygosity in oligodendroglial tumors |
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| المساهمون: | Se Hoon Kim, Hoguen Kim, Tai Seung Kim, Kim, Se Hoon, Kim, Tai Seung, Kim, Ho Keun |
| بيانات النشر: | Springer Germany |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adolescent, Adult, Age Factors, Aged, Biomarkers, Tumor/analysis, Brain Neoplasms/diagnosis, Brain Neoplasms/genetics, Brain Neoplasms/metabolism, Child, Chromosomes, Human, Pair 1, Pair 19, Female, Glioma/diagnosis, Glioma/genetics, Glioma/metabolism, Humans, Immunohistochemistry, Loss of Heterozygosity, Male, Middle Aged, Polymerase Chain Reaction, Sensitivity and Specificity, Survival Analysis, Oligodendroglioma, Chromosomes human pair 1, Chromosomes human pair 19, Histology |
| الوصف: | To identify a better diagnostic criteria for oligodendroglial tumors, we investigated the clinical, histological, and immunohistochemical features that would be able to predict a 1p/19q loss of heterozygosity (LOH) in these tumors. We performed a PCR-based LOH test with the 1p and 19q microsatellite markers by microdissecting tumor in 56 samples (44 oligodendrogliomas and 12 mixed oligoastrocytomas) of paraffin-embedded tissue. Patients with oligodendroglial tumors with 1p/19q LOH had a statistically significant better prognosis for overall survival. Comparative analysis of several features indicated that the 1p/19q LOH tumors were associated with two histological features, �쐔umor cellularity�� and �쐏erinuclear halo,�� and low O 6-methylguanine-DNA-methyltransferase (MGMT) expression and high cytoplasmic glutathione S-transferase pi (GST-�) expression. In addition, the incidence of 1p/19q LOH was infrequent in the youngest age category (less than 20 years old) studied. Using the new features, we could predict the 1p/19q status of oligodendroglial tumors with greater than 90% accuracy. Therefore, applying these features in clinical practice, would be helpful in clarifying oligodendroglial tumor diagnosis. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0001-6268 0942-0940 |
| العلاقة: | ACTA NEUROCHIRURGICA; J00018; OAK-2005-11631; https://ir.ymlib.yonsei.ac.kr/handle/22282913/150896Test; http://link.springer.com/article/10.1007%2Fs00401-005-1020-xTest; T200500621; ACTA NEUROCHIRURGICA, Vol.110(1) : 27-38, 2005 |
| DOI: | 10.1007/s00401-005-1020-x |
| الإتاحة: | https://doi.org/10.1007/s00401-005-1020-xTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/150896Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.6C7ED9C |
| قاعدة البيانات: | BASE |
| تدمد: | 00016268 09420940 |
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| DOI: | 10.1007/s00401-005-1020-x |