التفاصيل البيبلوغرافية
| العنوان: |
Ketamine-Induced Disruption of Verbal Self- Monitoring Linked to Superior Temporal Activation. |
| المؤلفون: |
Stone, J. M., Abel, K. M., Allin, M. P. G., van Haren, N., Matsumoto, K., McGuire, P. K., Fu, C. H. Y. |
| المصدر: |
Pharmacopsychiatry; Jan2011, Vol. 44 Issue 1, p33-38, 6p |
| مصطلحات موضوعية: |
KETAMINE, SPEECH disorders, PEOPLE with schizophrenia, PHARMACOLOGY, PLACEBOS, MAGNETIC resonance imaging |
| مستخلص: |
Introduction: Misattribution of distorted selfgenerated speech in patients with schizophrenia has been associated with increased lateral temporal activation. As a pharmacological model of schizophrenia, we tested whether ketamine would induce the same eff ects in healthy individuals. Methods: Participants were 8 healthy male volunteers who were naïve to ketamine (mean age: 28 years). Ketamine (0.23 mg / kg bolus followed by 0.64 mg / kg / h) and placebo infusions were administered in a double-blind, randomised order, during 2 functional magnetic resonance imaging (fMRI) sessions. Each fMRI session consisted of a verbal self-monitoring task in which auditory feedback was experimentally modified. Results: Ketamine was associated with psychotic and dissociative symptoms. Participants made more misattributions of distorted selfgenerated speech ( p < 0.02) during the ketamine infusion. Ketamine led to reduced activation in the left superior temporal cortex during self-distorted speech, regardless of whether the speech was identified correctly or not, as compared to the placebo infusion. Misidentification of speech that had been distorted was not associated with any increase in brain activation in during the placebo infusion, however ketamine-induced misattributions were associated with a relative increase in left superior temporal cortex activation. Discussion: These data are consistent with the notion that self-monitoring impairments nderlie psychotic symptoms and suggest that N -methyl- D -aspartate (NMDA) receptor dysfunction may mediate self-monitoring eficits and psychotic phenomena in schizophrenia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
