| مستخلص: |
A new cycloartane-type triterpene named cycloartane-1?,2?,3?,25-tetraol (neomyrrhaol) ( 1), along with four known terpenes, sandaracopimaric acid ( 2), abietic acid ( 3), 2-methoxy-5-acetoxyfruranogermacr-1(10)-en-6-one ( 4), and dehydroabietic acid ( 5) have been isolated from the resin of COMMIPHORA MYRRHA. Their structures were elucidated by means of 1D, 2?D NMR and HR-mass spectroscopy. Compounds 2 - 5 are known compounds but not previously isolated from the resin of C. MYRRHA. Compounds 4 and 5 exhibited significant aromatase inhibiting activity with IC 50values at 0.2 ?M and 0.3 ?M, respectively. As shown in the MTT assay, 2, 3, 4, and 5 had inhibitory effects on HUVEC growth with IC 50values of 0.122 ?M ( 2), 0.125 ?M ( 3), 0.069 ?M ( 5). Compounds 1 - 5 did not inhibit contraction of the isolated uterine and did not protect HUVEC from damage induced by H 2O 2at the tested concentration. [ABSTRACT FROM AUTHOR] |
