Antiviral and Antiplasmodial Spirodihydrobenzofuran Terpenes from the FungusStachybotrys nephrospora
| العنوان: | Antiviral and Antiplasmodial Spirodihydrobenzofuran Terpenes from the FungusStachybotrys nephrospora |
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| المؤلفون: | Supaporn Sawadjoon, Yodhathai Thebtaranonth, Masahiko Isaka, Kanyawim Kirtikara, Prasat Kittakoop, Siribhorn Madla |
| المصدر: | Planta Medica. 70:1085-1087 |
| بيانات النشر: | Georg Thieme Verlag KG, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Stereochemistry, Plasmodium falciparum, Pharmaceutical Science, Stachybotrys, Herpesvirus 1, Human, Microbial Sensitivity Tests, Pharmacognosy, Antiviral Agents, Analytical Chemistry, Microbiology, Terpene, Antimalarials, Parasitic Sensitivity Tests, Chlorocebus aethiops, Drug Discovery, Animals, Humans, Malaria, Falciparum, Vero Cells, IC50, Mycelium, Pharmacology, chemistry.chemical_classification, biology, Plant Extracts, Organic Chemistry, Herpes Simplex, Fungi imperfecti, biology.organism_classification, Complementary and alternative medicine, chemistry, Vero cell, Molecular Medicine, Lactone, Phytotherapy |
| الوصف: | Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 microg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 microg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions. |
| تدمد: | 1439-0221 0032-0943 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0249d10695dc9c1b7d90ecba7ad60147Test https://doi.org/10.1055/s-2004-832652Test |
| رقم الانضمام: | edsair.doi.dedup.....0249d10695dc9c1b7d90ecba7ad60147 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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