التفاصيل البيبلوغرافية
| العنوان: |
Hemostasis Abnormalities in Patients with Vascular Dementia and Alzheimer’s Disease |
| المؤلفون: |
Mari, D, Parnetti, L, Coppola, R, Bottasso, B, Reboldi, G P, Senin, U, Mannucci, P M |
| المصدر: |
Thrombosis and Haemostasis ; volume 75, issue 02, page 216-218 ; ISSN 0340-6245 2567-689X |
| بيانات النشر: |
Georg Thieme Verlag KG |
| سنة النشر: |
1996 |
| الوصف: |
Summary Since it has not been established to what extent abnormalities of hemostasis contribute to the occurrence and development of dementia, selected measurements of coagulation and fibrinolysis were obtained in elderly patients with Alzheimer’s disease (n = 22) or vascular dementia (n = 29), compared with healthy individuals in the same age range (n = 61). Hemostasis abnormalities were more frequent and marked in vascular dementia, being expressed as significant increases of plasminogen activator inhibitor type 1, von Willebrand factor, D-dimer. and activated factor VII. However, some hemostasis measurements (von Willebrand factor, activated factor VII) were abnormally high also in the patients with Alzheimer’s disease, a condition in which vascular damage is not considered to play a major pathogenetic role. It could not be established in this study whether or not these hemostatic abnormalities play a causal role in the pathogenesis of dementia, or whether they are secondary to inflammation and chronic vascular disease. Nevertheless, their presence may contribute to aggravating vascular disease. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1055/s-0038-1650246 |
| DOI: |
10.1055/s-0038-1650246.pdf |
| الإتاحة: |
https://doi.org/10.1055/s-0038-1650246Test |
| رقم الانضمام: |
edsbas.E96E0F78 |
| قاعدة البيانات: |
BASE |
