Effects of Repeated Courses of Antenatal Corticosteroids on Somatic Development in Children 6 to 10 Years of Age
| العنوان: | Effects of Repeated Courses of Antenatal Corticosteroids on Somatic Development in Children 6 to 10 Years of Age |
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| المؤلفون: | William Gibb, Robin C Walker, Mark Walker, Xi-Kuan Chen, Shi Wu Wen, Margaret L. Lawson, Jane Lougheed |
| المصدر: | American Journal of Perinatology. 25:021-028 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Pediatrics, medicine.medical_specialty, Percentile, Hydrocortisone, Cephalometry, medicine.drug_class, Body Mass Index, Cohort Studies, Adrenal Cortex Hormones, Pregnancy, Heart rate, medicine, Humans, Child, Saliva, Decreased head circumference, Retrospective Studies, Morning, business.industry, Obstetrics and Gynecology, Retrospective cohort study, Blood pressure, Case-Control Studies, Prenatal Exposure Delayed Effects, Pediatrics, Perinatology and Child Health, Corticosteroid, Female, business, Body mass index |
| الوصف: | This study assessed the effects of repeated courses of antenatal corticosteroids on biometric characteristics, salivary cortisol, and heart function in children 6 to 10 years of age using a retrospective cohort study. Twenty-nine children whose mothers had received two or more courses of antenatal corticosteroids were identified from hospital charts. Eighty-seven children whose mothers did not receive antenatal corticosteroids were frequency matched with the exposed group by child's age, sex, and ethnicity. The body development, heart function, and salivary corticosteroid level were evaluated at 6 to 10 years of age. The percentiles of body measurements were calculated based on the 2000 Centers for Disease Control and Prevention growth charts. The general linear models were applied to assess the observed association. Decreased head circumference ( P = 0.017) and body mass index (BMI) ( P = 0.047) in children 6 to 10 years of age were associated with repeated courses of antenatal corticosteroids. Morning salivary cortisol level was lower in the exposed group than the unexposed group ( P = 0.048). No difference was found in height, weight, blood pressure, heart rate, and echocardiogram measurements between the two groups. Repeated courses of antenatal corticosteroid therapy are associated with decreased head circumference, BMI, and salivary cortisol level in children 6 to 10 years of age. |
| تدمد: | 1098-8785 0735-1631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54253421f5bd299d0ee4b76ccb175fafTest https://doi.org/10.1055/s-2007-995222Test |
| رقم الانضمام: | edsair.doi.dedup.....54253421f5bd299d0ee4b76ccb175faf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10988785 07351631 |
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