Immobilization-Dependent Bone Collagen Breakdown Appears to Increase with Time: Evidence for a Lack of a New Bone Equilibrium in Response to Reduced Load During Prolonged Bed Rest
| العنوان: | Immobilization-Dependent Bone Collagen Breakdown Appears to Increase with Time: Evidence for a Lack of a New Bone Equilibrium in Response to Reduced Load During Prolonged Bed Rest |
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| المؤلفون: | C. Scebba, Carmelo Erio Fiore, F. Ciffo, P. Pennisi, A. Amico, S. Di Fazzio |
| المصدر: | Hormone and Metabolic Research. 31:31-36 |
| بيانات النشر: | Georg Thieme Verlag KG, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Deoxypyridinoline, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Bed rest, Biochemistry, Bone and Bones, Collagen Type I, Bone resorption, Weight-Bearing, Immobilization, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Humans, Paralysis, Amino Acids, Bone Resorption, Aged, Pyridinoline, Chemistry, Biochemistry (medical), General Medicine, Middle Aged, Skeleton (computer programming), Resorption, Cerebrovascular Disorders, Alkaline phosphatase, Female, Bone Remodeling, Collagen, Peptides, Bed Rest, Biomarkers, Type I collagen |
| الوصف: | The purpose of this study was to evaluate the effect of prolonged immobilization on bone, in order to investigate how skeletal turnover adapts to bed rest. We examined indices of bone formation and bone resorption in the serum and urine of fifty-four patients (26 males and 28 females) immobilized after an episode of paralytic stroke. The length of immobilization ranged from 30 to 180 days. A significant, time-dependent increase in markers of resorption - urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr), serum Type I collagen cross-linked C-telopeptide (ICTP) - was observed in immobilized patients, as compared to free-living healthy subjects. The positive correlation between resorption markers increase and the length of immobilization suggests that the rate of bone resorption did not decrease with time. On the other hand, the levels of markers of bone formation - bone-specific alkaline phosphatase (B-ALP), and the carboxyl-terminal propeptide of Type I procollagen (PICP) - remained within the normal range in all patients, regardless the length of immobilization. Our results would indicate an uncoupling between bone formation and bone resorption during bed rest, and suggest that the bone collagen break-down was not a self-limiting process in immobilized patients, and that a new equilibrium or "steady state" in response to the reduced load was not reached in the skeleton. |
| تدمد: | 1439-4286 0018-5043 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44036117cff5075c1c394645a4ae570Test https://doi.org/10.1055/s-2007-978693Test |
| رقم الانضمام: | edsair.doi.dedup.....a44036117cff5075c1c394645a4ae570 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394286 00185043 |
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